Virtual screening and in vitro validation identifies the first reported inhibitors of Salmonella enterica HPPK. Issue 10 (2nd September 2021)

• Record Type: Journal Article
• Authors: Müller, Ronel; Gerwel, Tiaan M.; Kimuda, Magambo Phillip; Bishop, Özlem Tastan; Veale, Clinton G. L.; Hoppe, Heinrich C.
• Is Part Of: RSC medicinal chemistry. Volume 12:Issue 10(2021)
• Page Start: 1750
• Page End: 1756
• Publication Date: 2021-09-02
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1039/d1md00237f
• Languages: English
• ISSNs: 2632-8682

Abstract

Abstract : In this study we report the first inhibitors of Salmonella enterica HPPK. The compounds identified are structurally distinct from E.coli and S. aureus HPPK inhibitors, and offer new opportunities for expanding HPPK inhibitor space. Abstract : HPPK, which directly precedes DHPS in the folate biosynthetic pathway, is a promising but chronically under-exploited anti-microbial target. Here we report the identification of new S. enterica HPPK inhibitors, offering potential for new resistance circumventing S. enterica therapies as well as avenues for diversifying the current HPPK inhibitor space.