ESRA19-0317 Effect of preoperative gabapentin on intraoperative and postoperative pain in paediatric urogenital surgeries: a randomized controlled trial. (30th August 2019)

• Record Type: Journal Article
• Authors: Nanda, S; Sinha, C; Kumar, A
• Is Part Of: Regional anesthesia and pain medicine. Volume 44(2019)Supplement 1
• Page Start: A196
• Page End: A196
• Publication Date: 2019-08-30
• Subjects: Conduction anesthesia -- Periodicals; Pain medicine -- Periodicals; 617.964
• DOI: 10.1136/rapm-2019-ESRAABS2019.332
• Languages: English
• ISSNs: 1098-7339

Abstract

Abstract : Background and aims: Our aim was to determine the effect of Gabapentin on acute pain in the immediate postoperative period in paediatric patients undergoing urogenital surgeries under general anaesthesia. Methods: After approval by the Institutional Ethical Committee, 60 patients of ages 8 to 17 years scheduled to undergo elective surgeries were included. After obtaining a written, informed consent, on the day of the surgery, the patients were administered 5 ml of milk, with (Group A) or without (Group B) 15 mg/kg of Gabapentin 2 hours prior to surgery. All patients were subjected to induction with injection Propofol 2 mg/kg, vecuronium (0.1 mg/kg), fentanyl (2 mic/kg), patients were maintained on air + sevoflurane mixture. Postoperatively, patients were given Fentanyl boluses until either the Numeric Rating Score (NRS) <3 or the Respiratory Rate (RR) was <12. The observer assessed pain on NRS and sedation on Ramsay Sedation Scale (RSS) at 0, 1, 4, 8, 16, and 24 hours. Results: The demographic data was comparable. The results showed that there was significant decrease in the intraoperative and postoperative requirement of Fentanyl in Group I (0.733+_0.47, 0.916+_0.343 micrograms) compared to Group II (1.216+_0.512, 1.333+_0.4887 micrograms) respectively. The time for first rescue analgesic was significantly higher in Group I (6.033+_1.70 hours) vs that in Group II (3.866+_0.76 hours). The NRS were significantly lower and RSS were higher in the first 4 hours in Group I vs Group II Conclusions: The preoperative administration of Gabapentin (15 mg/kg) reduces the intraoperative consumption, postoperative consumption of Fentanyl during the first four hours and delays the demand for first rescue analgesic.