Kinetic resolution of N-aryl β-amino alcohols via asymmetric aminations of anilines. Issue 74 (24th August 2021)

• Record Type: Journal Article
• Authors: Guo, Zheng; Xie, Jinglei; Hu, Tao; Chen, Yunrong; Tao, Houchao; Yang, Xiaoyu
• Is Part Of: Chemical communications. Volume 57:Issue 74(2021)
• Page Start: 9394
• Page End: 9397
• Publication Date: 2021-08-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc03117a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An efficient kinetic resolution of N -aryl β-amino alcohols has been developed via asymmetric para -aminations of anilines with azodicarboxylates enabled by chiral phosphoric acid catalysis. Abstract : An efficient kinetic resolution of N -aryl β-amino alcohols has been developed via asymmetric para -aminations of anilines with azodicarboxylates enabled by chiral phosphoric acid catalysis. Broad substrate scope and high kinetic resolution performances were afforded with this method. Control experiments supported the critical roles of the NH and OH group in these reactions.