Commandeering the mammalian Ago2 miRNA network: a newly discovered mechanism of helminth immunomodulation. Issue 12 (December 2021)

• Record Type: Journal Article
• Authors: Donnelly, Sheila; Tran, Nham
• Is Part Of: Trends in parasitology. Volume 37:Issue 12(2021)
• Page Start: 1031
• Page End: 1033
• Publication Date: 2021-12
• Subjects: Fasciola hepatica -- helminth -- microRNAs -- Argonaut -- extracellular vesicles; Parasitology -- Periodicals; Parasitology -- Periodicals; Biology -- Periodicals; Parasitology; Biology; Parasitologie -- Périodiques; Online resources; 571.999
• DOI: 10.1016/j.pt.2021.09.001
• Languages: English
• ISSNs: 1471-4922

Abstract

Abstract : MicroRNAs (miRNAs) are a class of noncoding RNAs that contribute to a broad range of biological processes through post-transcriptional regulation of gene expression. Helminths exploit this system to target mammalian gene expression, to modulate the host immune response. Recent discoveries have shed new light on the mechanisms involved.