Type 2 diabetes prevention diet and the risk of pancreatic cancer: A large prospective multicenter study. Issue 11 (November 2021)

• Record Type: Journal Article
• Authors: Huang, Yan; Liu, Feng; Chen, A-Mei; Yang, Peng-Fei; Peng, Yang; Gong, Jian-Ping; Li, Zhi; Zhong, Guo-Chao
• Is Part Of: Clinical nutrition. Volume 40:Issue 11(2021)
• Page Start: 5595
• Page End: 5604
• Publication Date: 2021-11
• Subjects: Dietary pattern -- Pancreatic cancer -- Cancer prevention -- Epidemiology; BMI body mass index -- CI confidence interval -- DHQ diet history questionnaire -- HR hazard ratio -- PLCO Prostate, Lung, Colorectal, and Ovarian; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2021.09.037
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aims: Type 2 diabetes prevention diet confers a lower risk of type 2 diabetes, which exhibits overlapping mechanisms with pancreatic cancer. We performed a prospective study to examine whether adherence to this dietary pattern is associated with a reduced risk of pancreatic cancer. Methods: A population-based cohort of 101, 729 American adults was identified. A dietary diabetes risk reduction score was computed to reflect adherence to this dietary pattern, with higher scores representing greater adherence. Cox regression was used to compute hazard ratios (HRs) for pancreatic cancer incidence. Prespecified subgroup analyses were used to identify the potential effect modifiers. Results: After an average follow-up of 8.86 years (900, 871.67 person-years), a total of 402 pancreatic cancer cases were observed. In the fully adjusted model, participants in the highest quartile of dietary diabetes risk reduction score were found to have a reduced risk of pancreatic cancer compared with those in the lowest quartile [HRquartiles 4 versus 1 : 0.62; 95% confidence interval (CI): 0.44, 0.86; P trend = 0.004], which remained in a series of sensitivity analyses. Subgroup analyses further found that this favorable association was more pronounced in current or former smokers (HRquartiles 4 versus 1 : 0.48; 95% CI: 0.30, 0.77) than in never smokers (HRquartiles 4 versus 1 : 0.71; 95% CI: 0.44, 1.15), although the interaction test did not reach statistical significance ( P interaction = 0.095). Conclusions: Greater adherence to type 2 diabetes prevention diet is associated with a lower risk of pancreatic cancer in this US population. More studies are needed to confirm our findings. Highlights: No prospective study has examined the association of type 2 diabetes prevention diet with the risk of pancreatic cancer. Adherence to type 2 diabetes prevention diet was associated with a reduced risk of pancreatic cancer. The beneficial role of type 2 diabetes prevention diet was more evident in current or past smokers than in never smokers.