Semi-automated and interactive segmentation of contrast-enhancing masses on breast DCE-MRI using spatial fuzzy clustering. (January 2022)

• Record Type: Journal Article
• Authors: Militello, Carmelo; Rundo, Leonardo; Dimarco, Mariangela; Orlando, Alessia; Conti, Vincenzo; Woitek, Ramona; D'Angelo, Ildebrando; Bartolotta, Tommaso Vincenzo; Russo, Giorgio
• Is Part Of: Biomedical signal processing and control. Volume 71(2022)Part A
• Publication Date: 2022-01
• Subjects: Semi-automated segmentation -- Breast cancer -- Unsupervised fuzzy clustering -- Spatial information -- Computer-assisted lesion detection -- Magnetic Resonance Imaging; Signal processing -- Periodicals; Biomedical engineering -- Periodicals; Signal Processing, Computer-Assisted -- Periodicals; Image Processing, Computer-Assisted -- Periodicals; Biomedical Engineering -- Periodicals; 610.28
• DOI: 10.1016/j.bspc.2021.103113
• Languages: English
• ISSNs: 1746-8094

Abstract

Graphical abstract: Highlights: Semi-automated and interactive method for segmenting contrast-enhancing breast masses. Unsupervised Fuzzy C-Means clustering with spatial information was used. The method was evaluated in terms of segmentation accuracy and volume correlation. Our approach outperformed existing work based on classic literature image processing, as well as SegNet and U-Net. Computer-assisted segmentation could be deployed into clinical research environments. Abstract: Multiparametric Magnetic Resonance Imaging (MRI) is the most sensitive imaging modality for breast cancer detection and is increasingly playing a key role in lesion characterization. In this context, accurate and reliable quantification of the shape and extent of breast cancer is crucial in clinical research environments. Since conventional lesion delineation procedures are still mostly manual, automated segmentation approaches can improve this time-consuming and operator-dependent task by annotating the regions of interest in a reproducible manner. In this work, a semi-automated and interactive approach based on the spatial Fuzzy C-Means (sFCM) algorithm is proposed, used to segment masses on dynamic contrast-enhanced (DCE) MRI of the breast. Our method was compared against existing approaches based on classic image processing, namely ( i ) Otsu's method for thresholding-based segmentation, and ( ii ) the traditional FCM algorithm. A further comparison was performed against state-of-the-art Convolutional Neural Networks (CNNs) for medical image segmentation, namely SegNet and U-Net, in a 5-fold cross-validation scheme. The results showed the validity of the proposed approach, by significantly outperforming the competing methods in terms of the Dice similarity coefficient ( 84.47 ± 4.75 ). Moreover, a Pearson's coefficient of ρ = 0.993 showed a high correlation between segmented volume and the gold standard provided by clinicians. Overall, the proposed method was confirmed to outperform the competing literature methods. The proposed computer-assisted approach could be deployed into clinical research environments by providing a reliable tool for volumetric and radiomics analyses.