A triple-targeting delivery system carrying two anticancer agents. Issue 37 (8th July 2021)

• Record Type: Journal Article
• Authors: Li, Hui; Lee, Chang-Hee; Shin, Injae
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 37(2021)
• Page Start: 8009
• Page End: 8013
• Publication Date: 2021-07-08
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob01089a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : To improve tumor selectivity, we prepared a new triple-targeting delivery system bearing two anticancer agents. Both anticancer agents in this system are released in the presence of both H2 O2 and cathepsin B which are highly produced in cancer cells. Abstract : To improve tumor selectivity, a triple-targeting delivery system (Oct-FK(PBA-Az)-Dox) carrying two anticancer agents (apoptozole (Az) and doxorubicin (Dox)) was designed and synthesized. The results showed that both anticancer agents in Oct-FK(PBA-Az)-Dox are liberated in the presence of both H2 O2 and cathepsin B, which are normally present at high levels in tumors.