213 Cervical cancer screening program with primary DNA-HPV test started in 2017 in brazilian city: results after 18 months. (18th September 2019)

• Record Type: Journal Article
• Authors: Teixeira, J; Discacciati, MG; Moraes, DDRPL; Vale, DB; Couto, TT; Zeferino, LC
• Is Part Of: International journal of gynecological cancer. Volume 29(2019)Supplement 3
• Page Start: A93
• Page End: A93
• Publication Date: 2019-09-18
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2019-IGCS.213
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objectives: Report preliminary results after 18 months of the new Cervical Cancer Screening Program with primary DNA-HPV test (CCSP-HPV), performed at Indaiatuba city, Sao Paulo State, Brazil. Methods: Indaiatuba has 240 thousand people with 50% assisted by Public Health System (SUS). Until 2017, CCSP was performed by conventional cytology (∼9, 000/year), but with <30% coverage of target women (25–64yo). CCSP-HPV was built based in National guideline replacing cytology by Cobas® HPV Test performed at 5-year intervals. Target population comprehend 28, 000 women, and the goals will be to reach 80% of coverage after first round (5y). The CCSP-HPV started in October 2017, and here we present the 18-months results compared with previous years (2011–2016, conventional cytology). Results: We considered 9, 974 HPV tests in the CCSP-HPV, 95% coverage at 18-months versus 50, 708 cytology tests from 2011–2016. 99, 2% of the HPV tests were performed in age-range 25–64yo against 77.3% by cytology (0.5% vs 16.6% before the age of 25). Only 22.3% of cytology screening followed guideline for interval (3y). In general, unsatisfactory samples were <0.5% for both programs. Tests results were negative in 96.7% (n=9, 643) for HPV tests vs. 98.3% for cytology. HPV-16 and/or -18 were tested positive in 331 (3.3%), and 'Other 12-HR-HPV' in 911 (9.1%), with 254 abnormal cytology exams (2.5% colposcopy referral). Total colposcopy referral was 3.4 times more (5.8%/1.7%) than previous opportunistic screening. Conclusions: Organized screening program with primary HPV test indicated high coverage and compliance of target age-range after 18-months, with less unsatisfactory samples, and more referral to colposcopy.