299 Precision oncology in surgery: patient selection for operable recurrent hepatic ovarian cancer. (18th September 2019)

• Record Type: Journal Article
• Authors: Gallotta, V; Conte, C; D'Indinosante, M; Capoluongo, E; Angelo, M; De Rose Maria, A; Ardito, F; Giuliante, F; Di Giorgio, A; Zannoni, GF; Margreiter, C; Scambia, G; Ferrandina, G
• Is Part Of: International journal of gynecological cancer. Volume 29(2019)Supplement 3
• Page Start: A125
• Page End: A125
• Publication Date: 2019-09-18
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2019-IGCS.299
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objectives: To describe accurately the oncological outcomes after hepatic resection (HR) in recurrent ovarian carcinoma (ROC) evaluating clinic-pathological variables and mutational status of BRCA1/2. Although HR is considered a challenging situation in ROC patients, assessment of BRCA1/2 mutational status seems to have a relevant clinical value to guide surgical therapy. Methods: Patients who underwent HR for ROC at the Catholic University of Rome, between June 2012 and October 2017 were included. Exclusion criteria were represented by extra-abdominal disease and presence of diffuse peritoneal carcinomatosis requiring more than 2 bowel resections. Details relative to HR were collected and BRCA analysis was performed. Predictive factors for of post-relapse progression free survival (PHR-PFS)were assessed by univariate analyses using Cox-proportional hazard regression models. Results: Thirty-four patients undewent HR within secondary cytoreductive surgery (SCS). Six patients (17.6%) presented with hepatic relapse only, while the remaining 28 patients (82.4%) had concomitant extra-hepatic disease. In the whole series, the 3-yr PHR-PFS was 49.1% and the 3-yr progression free survival overall survivalwas 72.9%. Univariate analysis of variables conditioning PHR-PFS showed that only BRCA mutational status played a statistically significant favourable role: the 3-yr PHR-PFS rate was 81.0% in BRCA mutated patient compared to15.2% in wild type ones (p value: 0.001). Conclusions: Our clinical analyses suggest that in ROC patients with liver disease the assessment of BRCA mutational status can help to select patients elegible for SCS.