Development and validation of a novel nomogram predicting 10-year actual survival after curative hepatectomy for hepatocellular carcinoma. Issue 6 (December 2021)

• Record Type: Journal Article
• Authors: Ng, Kelvin K.C.; Cheng, Nicole M.Y.; Huang, Jiwei; Liao, Mingheng; Chong, Charing C.N.; Lee, Kit-Fai; Wong, John; Cheung, Sunny Y.S.; Lok, Hon-Ting; Fung, Andrew K.Y.; Wong, Grace L.H.; Wong, Vincent W.S.; Lai, Paul B.S.
• Is Part Of: Surgeon. Volume 19:Issue 6(2021)
• Page Start: 329
• Page End: 337
• Publication Date: 2021-12
• Subjects: Nomogram -- 10-year -- Survivor -- Hepatocellular -- Carcinoma -- Hepatectomy; Surgery -- Periodicals; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; 617
• DOI: 10.1016/j.surge.2020.11.013
• Languages: English
• ISSNs: 1479-666X

Abstract

Abstract: Introduction: Although hepatectomy is a curative treatment modality for hepatocellular carcinoma (HCC), the associated 10-year long-term actual survival are rarely reported. This study aims to develop and validate a predictive nomogram for 10-year actual survivors with HCC. Materials and methods: From 2004 to 2009, 753 patients with curative hepatectomy for HCC (development set, n = 325; validation set, n = 428) were included. In development set, comparison of clinic-pathological data was made between patients surviving ≥10 years and those surviving <10 years. Good independent prognostic factors identified by multivariate analysis were involved in a nomogram development, which was validated internally and externally using validation set. Results: On multivariate analysis, five independent good prognostic factors for 10-year survival were identified, including young age (OR = 0.943), good ASA status (≤2) (OR = 2.794), higher albumin level (OR = 1.116), solitary tumor (OR = 2.531) and absence of microvascular invasion (OR = 3.367). A novel nomogram was constructed with C -index of 0.801 (95% CI 0.762–0.864). A cut-off point of 167.5 had a sensitivity of 0.794 and specificity of 0.730. Internal validation using bootstrap sampling and external validation using validation set revealed C -index of 0.792 (95% CI, 0.741–0.853) and 0.761 (95% CI, 0.718–0.817). Conclusion: A novel nomogram for 10-year HCC survivor using age, ASA status, preoperative albumin, tumor number and presence of microvascular tumor invasion was developed and validated with high accuracy. Highlights: A novel nomogram predicting 10-year actual overall survival of patients with HCC following hepatectomy was developed. Five prognostic factors, i.e. age, ASA status, albumin, tumor number and microvascular tumor invasion in the nomogram. The first nomogram in the world predicting long-term survival in patients with HCC, with discriminative power. One of the largest cohort of patients with HCC documenting an actual 10-year overall survival rate of 29.2% in Hong Kong cohort and 26.1% in China cohort.