262 Obesity-related neutrophilia in endometrial cancer. (18th September 2019)

• Record Type: Journal Article
• Authors: Cheung, M; O'Brien, O; Byrne, D; Geoghegan, T; LeRoux, C; Brennan, D
• Is Part Of: International journal of gynecological cancer. Volume 29(2019)Supplement 3
• Page Start: A111
• Page End: A111
• Publication Date: 2019-09-18
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2019-IGCS.262
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objectives: Obesity and metabolic syndrome are significant risk factors for endometrial cancer (EC). This case-control study aimed to assess the relationship between visceral fat and systemic inflammatory markers in EC and cervical cancer (CC). Methods: ImageJ software was used to measure the visceral fat percentage (VFP) on a L3/4 CT slice, for 22 EC, 20 CC. Pre-treatment full blood counts were used to assess inflammatory ratios. Results: Mean BMI (32.56 vs 25.87 kg/m 2, p=0.03) and VFP (33.4 vs 24.0%, p=0.0018) was higher in EC compared to CC patients. BMI did not correlate with VFP. Mean pre-operative leukocytes (8.5 vs 7, p=0.044) and neutrophils (5.85 vs 4.32, p=0.019) were higher in EC patients. There was no difference in the lymphocyte-neutrophil-ratio or lymphocyte-monocyte-ratio, however the neutrophil-monocyte-ratio (NMR) was higher in the EC group (11.27 vs 8.28, p=0.018). This was due to the significant neutrophilia in the EC group (68.9% vs 60.5%, p=0.037) as there was no difference in monocytes in either group. No inflammatory ratio correlated with VFP. Conclusions: VFP and BMI do not correlate, and no white cell ratio correlated with either value in this study. Obesity related neutrophilia may be an important target in EC that warrants further investigation