Overview of malignant soft-tissue sarcomas of the limbs. Issue 12 (December 2021)

• Record Type: Journal Article
• Authors: Renn, A.; Adejolu, M.; Messiou, C.; Bhaludin, B.; Strauss, D.C.; Thway, K.; Moskovic, E.
• Is Part Of: Clinical radiology. Volume 76:Issue 12(2021)
• Page Start: 940.e1
• Page End: 940.e16
• Publication Date: 2021-12
• Subjects: Medical radiology -- Periodicals; Radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiology -- Periodicals; Societies, Medical -- Periodicals; Medical radiology; Radiotherapy; Electronic journals; Periodicals; 616.0757
• DOI: 10.1016/j.crad.2021.08.011
• Languages: English
• ISSNs: 0009-9260

Abstract

Abstract : Although soft-tissue masses are common, sarcomas are rare malignant neoplasms showing variable mesenchymal differentiation and can occur at any anatomical site. Limb soft-tissue sarcomas (STS) are rare, but often lethal tumours. Although there are scores of historical pathological subtypes, this article will deal with the commonest: liposarcoma, leiomyosarcoma (LMS), undifferentiated pleomorphic sarcoma (UPS), synovial sarcoma, myxofibrosarcoma, malignant peripheral nerve sheath tumour (MPNST), epithelioid sarcoma, alveolar rhabdosarcoma, angiosarcoma and radiation-induced sarcoma (RIS). Following a review of >4, 000 adult patients with limb sarcoma from our specialist soft-tissue tumour database, we summarise the literature and their imaging findings, with emphasis on radiological hallmarks that can aide in diagnosis and management. Increased awareness of sarcoma when challenged with a new mass in the extremity can ensure timely and appropriate treatment.