214 Cervical cancer under 25 years-old in developed region from brazil: 15-years study. (18th September 2019)

• Record Type: Journal Article
• Authors: Santos, DZ; Souza, ECA; Toledo, MCS; Vale, DB; Braganca, JF; Teixeira, J
• Is Part Of: International journal of gynecological cancer. Volume 29(2019)Supplement 3
• Page Start: A93
• Page End: A93
• Publication Date: 2019-09-18
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2019-IGCS.214
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objectives to evaluate cervical cancer rate, stage, histology and survival in women under 25 years-old (yo). Methods we evaluated the cervical cancer registered in 2001–2015 by age-group, stage and histology based in Hospital Registry of Regional Hospital at developed region from Brazil (Campinas-SP), with 5 million people. The statistical analysis was done by Chi-square test, linear trend test, and survival by Kaplan-Meyer and log-rank test. Results: 2, 041 registries were analyzed: 32 (1.57%) with 15–24yo (only 0.29%, 6 cases up to 20yo), 96 in age-group 25–29yo, 164 in 30–34yo and 1, 749 in age >35yo. Cases in age >35yo decreased from 94.6% in 2001–03 to 80.8% in 2013–2015, although not significant (p=0.078). There was increased trend in proportion of cancer in younger age-groups (15–24/25–29/30–34yo, p=0.04/0.014/<0.001). Glandular histology had bigger proportion in women 15–24yo (6/32, 19%; 1/6 cases at age up to 20yo) than 25–29yo (11.5%), 30–34yo (14.0%) (p=0.008) Age-group under 25yo had 59% of the cancer in Stage I, while the age >35yo showed 67.1% of cancer in advanced Stages II-IV (p<0.001). Under 25yo the 5y-Survival rate was 76%, better for age 23–24yo (82%) than <22yo (66%), better for SCC (86%) than adenocarcinoma (43%), and for stage I (100% vs 46% for Stage II-IV). Conclusions diagnoses in age-group under 25yo had increasing trend although there were few cases in age up to 20yo. The proportion of glandular histology and disease in Stage I was higher in women under 25yo than age-group >35yo. Worse survival rate was related to youngers and adenocarcinoma histology.