No differences in muscle protein synthesis rates following ingestion of wheat protein, milk protein, and their protein blend in healthy, young males. Issue 12 (28th December 2021)

• Record Type: Journal Article
• Authors: Pinckaers, Philippe J.M.; Kouw, Imre W.K.; Hendriks, Floris K.; van Kranenburg, Janneau M.X.; de Groot, Lisette C.P.G.M.; Verdijk, Lex. B.; Snijders, Tim; van Loon, Luc J.C.
• Is Part Of: British journal of nutrition. Volume 126:Issue 12(2021)
• Page Start: 1832
• Page End: 1842
• Publication Date: 2021-12-28
• Subjects: Muscle protein synthesis -- Plant-based proteins -- Dairy -- Protein blends -- Fractional synthesis rate -- Young healthy males; Nutrition -- Periodicals; 572.4
• DOI: 10.1017/S0007114521000635
• Languages: English
• ISSNs: 0007-1145

Abstract

Abstract: Plant-derived proteins have been suggested to have less anabolic properties when compared with animal-derived proteins. Whether blends of plant- and animal-derived proteins can compensate for their lesser anabolic potential has not been assessed. The present study compares post-prandial muscle protein synthesis rates following the ingestion of milk protein with wheat protein or a blend of wheat plus milk protein in healthy, young males. In a randomised, double-blind, parallel-group design, 36 males (23 (sd 3) years) received a primed continuous L-[ring- 13 C6 ]-phenylalanine infusion after which they ingested 30 g milk protein (MILK), 30 g wheat protein (WHEAT) or a 30 g blend combining 15 g wheat plus 15 g milk protein (WHEAT+MILK). Blood and muscle biopsies were collected frequently for 5 h to assess post-prandial plasma amino acid profiles and subsequent myofibrillar protein synthesis rates. Ingestion of protein increased myofibrillar protein synthesis rates in all treatments ( P < 0·001). Post-prandial myofibrillar protein synthesis rates did not differ between MILK v . WHEAT (0·053 (sd 0·013) v . 0·056 (sd 0·012) %·h −1, respectively; t test P = 0·56) or between MILK v . WHEAT+MILK (0·053 (sd 0·013) v . 0·059 (sd 0·025) %·h −1, respectively; t test P = 0·46). In conclusion, ingestion of 30 g milk protein, 30 g wheat protein or a blend of 15 g wheat plus 15 g milk protein increases muscle protein synthesis rates in young males. Furthermore, muscle protein synthesis rates following the ingestion of 30 g milk protein do not differ from rates observed after ingesting 30 g wheat protein or a blend with 15 g milk plus 15 g wheat protein in healthy, young males.