Ruthenium-catalyzed N-alkylation of amino-1, 3, 5-triazines using alcohols. (9th August 2021)

• Record Type: Journal Article
• Authors: Zhao, Junna; Zhong, Pengzhen; Xie, Zhongpao; Zhou, Wei; Zhang, Chen; Cui, Dong-Mei
• Is Part Of: New journal of chemistry. Volume 45:Number 35(2021)
• Page Start: 15776
• Page End: 15779
• Publication Date: 2021-08-09
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d1nj03116c
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : An efficient ruthenium-catalyzed N -alkylation of amino-1, 3, 5-triazines with alcohols was achieved via BH/HA strategy. Abstract : An efficient ruthenium-catalyzed N -alkylation of amino 1, 3, 5-triazines with alcohols was achieved via a BH/HA strategy. Following this simple, facile, and high atom economical protocol, a broad range of products was prepared in moderate to good yields and heterocyclic or benzylic alcohols containing various functionalities were tolerated. The application of the reaction is also further demonstrated by the synthesis of alkylated secondary amine-1, 3, 5-triazines from olefinated amino-1, 3, 5-triazines and alcohols via a one pot N -alkylation and reductive reactions.