Effect of molecular chirality on the collagen self-assembly. (11th August 2021)

• Record Type: Journal Article
• Authors: Zhu, Weizhe; Li, Ke; Liu, Qi; Zhong, Huaying; Xu, Chengzhi; Zhang, Juntao; Kou, Huizhi; Wei, Benmei; Wang, Haibo
• Is Part Of: New journal of chemistry. Volume 45:Number 35(2021)
• Page Start: 15863
• Page End: 15868
• Publication Date: 2021-08-11
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d1nj02242c
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : The function of molecular chirality in collagen self-assembly was presented. Abstract : Chirality is a basic property of nature and plays an important role in several biological activities of living organisms. However, the function of chirality in the self-assembly of natural collagen is still unclear. Herein, we investigated the effect of chirality on the self-assembly of bovine Achilles tendon collagen (BATC) using d /l -glutamic acid (GA) as model molecules. Kinetic studies indicated that the rate of self-assembly of d -GA/BATC was faster than that of l -GA/BATC. Results from scanning electron microscopy showed that collagen fibrils assembled in the presence of l -GA had a larger diameter than those assembled in the presence of d -GA. Differential scanning calorimetry and viscoelasticity analyses confirmed that l -GA/BATC gel had better thermal stability and mobility than the corresponding d -GA/BATC gel. Collectively, these results indicated that molecular chirality can be used as a novel strategy to regulate the performance of collagen self-assembly products.