Stimuli-responsive transmembrane anion transport by AIE-active fluorescent probes. Issue 34 (17th August 2021)

• Record Type: Journal Article
• Authors: Akhtar, Nasim; Biswas, Oindrila; Manna, Debasis
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 34(2021)
• Page Start: 7446
• Page End: 7459
• Publication Date: 2021-08-17
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob00584g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Anticancer drug resistance implicates multifunctional mechanisms, and hypoxia is one of the key factors in therapeutic resistance. Herein, we report the development of AIE-active Cl − ion transporter which get activated under hypoxic environment. Abstract : Anticancer drug resistance implicates multifunctional mechanisms, and hypoxia is one of the key factors in therapeutic resistance. Hypoxia-specific therapy is considered an extremely effective strategy to fight against cancer. The development of small molecule-based synthetic anion transporters has also recently drawn attention for their potential therapeutic applications against several ion-transport-associated diseases, such as cancer and others. Herein, we describe the development of a hypoxia-responsive proanionophore to trigger controlled transport of anions across membranes under pathogenic conditions. Herein, we report the development of tetraphenylethene (TPE)-based anion transporters. The sulfonium-linked p -nitrobenzyl containing TPE-based proanionophore could be converted into a lipophilic fluorescent Cl − ion carrier in a hypoxic or reductive environment. Stimuli such as nitroreductase (NTR) and glutathione (GSH) mediated regeneration of the TPE-based active Cl − ion transporter also showed aggregation-induced emission (AIE) properties. We hypothesize that such hypoxia and reductive stimuli activatable proanionophores have tremendous potential to fight against channelopathies, including cancer.