Rh(iii)-Catalyzed C(sp2)–H functionalization/cyclization cascade of N-carboxamide indole and iodonium reagents for access to indoloquinazolinone derivatives. Issue 17 (11th August 2021)

• Record Type: Journal Article
• Authors: Han, Zhi-Peng; Xu, Meng-Meng; Zhang, Rui-Ying; Xu, Xiao-Ping; Ji, Shun-Jun
• Is Part Of: Green chemistry. Volume 23:Issue 17(2021)
• Page Start: 6337
• Page End: 6340
• Publication Date: 2021-08-11
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d1gc01820e
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : The sustainable synthesis of indoloquinazolinone derivatives from N -methoxycarbamoyl indoles and iodonium ylide reagents in methanol is described. Abstract : A rhodium-catalyzed synthesis of indoloquinazolinone from a readily available hypervalent iodonium reagent and N -carboxamide indole was developed. The protocol features broad functional group tolerance, mild conditions, and excellent yields. The target products were obtained simply by filtration, without tedious column chromatography. Notably, the noble metal catalyst system can be recycled effectively at least ten times. The strategy may be amenable to industrial production.