CircRNAs in gastric cancer: current research and potential clinical implications. Issue 21 (21st October 2021)

• Record Type: Journal Article
• Authors: Lu, Yixun; Li, Kai; Gao, Yunhe; Liang, Wenquan; Wang, Xinxin; Chen, Lin
• Is Part Of: FEBS letters. Volume 595:Issue 21(2021)
• Page Start: 2644
• Page End: 2654
• Publication Date: 2021-10-21
• Subjects: biomarker -- circRNA -- gastric cancer -- ncRNA -- therapeutic target; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.14196
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Gastric cancer (GC) has a dismal prognosis and is also one of the most commonly diagnosed malignancies worldwide. circRNAs are covalently closed circular RNA molecules without 5′‐cap and a 3′‐tail, currently listed among the broad noncoding RNA family. circRNAs participate in a variety of pathophysiological processes relevant to human diseases, especially malignancies, including GC. Compelling evidence has shown that circRNAs can function by sponging miRNAs, interacting with RNA binding proteins, and encoding proteins or peptides. Yet, our current understanding of these RNA circles remains very limited. Here, we overview the biogenesis, characteristics, functions, and degradation of circRNAs. Moreover, we give an account of the circRNAs that have been linked with GC, describing their functions and mechanisms of action in the context of GC. Next, we discuss the potential value of circRNAs as diagnostic or prognostic GC biomarkers and summarize future prospects, important questions, and challenges of circRNA‐based therapeutics. Abstract : Circular RNAs (circRNAs) participate in a variety of pathophysiological processes relevant to human diseases, including gastric cancer (GC). As such, circRNAs hold the promise to become novel therapeutic targets and diagnostic/prognostic biomarkers that may transform GC treatment.