COVID-19, circadian rhythms and sleep: from virology to chronobiology. Issue 6 (12th October 2021)

• Record Type: Journal Article
• Authors: Liu, Zulian; Ting, Sharlene; Zhuang, Xiaodong
• Is Part Of: Interface focus. Volume 11:Issue 6(2021)
• Publication Date: 2021-10-12
• Subjects: SARS-CoV-2 -- coronavirus -- dexamethasone -- healthcare workers -- vaccine; Physical sciences -- Periodicals; Life sciences -- Periodicals; 500
• DOI: 10.1098/rsfs.2021.0043
• Languages: English
• ISSNs: 2042-8898

Abstract

Abstract : Various aspects of our physiology and immune response to pathogens are under 24 h circadian control and its role in clinical and research practice is becoming increasingly recognized. Severe acute respiratory syndrome coronavirus-2, the causative agent of Coronavirus disease 2019 (COVID-19) has affected millions of people to date. Cross-disciplinary approaches and collaborative efforts have led to an unprecedented speed in developing novel therapies and vaccines to tackle the COVID-19 pandemic. Circadian misalignment and sleep disruption have a profound impact on immune function and subsequently on the ability of individuals to combat infections. This review summarizes the evidence on the interplay between circadian biology, sleep and COVID-19 with the aim to identify areas of translational potentials that may inform diagnostic and therapeutic strategies in this pandemic.