Chiral Recognition on Bare Gold Surfaces by Quartz Crystal Microbalance. (20th October 2021)

• Record Type: Journal Article
• Authors: Xiao, Xiangyun; Chen, Chao; Zhang, Yehao; Kong, Huihui; An, Rong; Li, Shuang; Liu, Wei; Ji, Qingmin
• Is Part Of: Angewandte Chemie. Volume 133:Number 47(2021)
• Page Start: 25232
• Page End: 25237
• Publication Date: 2021-10-20
• Subjects: amino acid -- chiral recognition -- density functional theory -- metal surface -- quartz crystal microbalance; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202110187
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Quartz crystal microbalance (QCM) is one of the powerful tools for the studies of molecular recognition and chiral discrimination. Its efficiency mainly relies on the design of the functional sensitive layer on the electrode surface. However, the organic sensitive layer may easily cause dissipation of oscillation or detachment and weaken the signal transfer during the molecular recognition processes. In this work, we reveal for the first time that the bare metal surface without the organic selector layer has the capability for chiral recognition in the QCM system. During the adsorption of various chiral amino acids, relatively higher selectivity of D‐enantiomers on gold (Au) surface was shown by the QCM detection. Based on analyses of the surface crystalline structure and density functional theory calculations, we demonstrate that the chiral nature of Au surface plays an important role in the selective binding of specific D‐amino acids. These results may open new insights on chiral detection by QCM system. It will also promote the construction of novel chiral sensing systems with both efficient detection and separation capability. Abstract : Based on the quartz crystal microbalance (QCM) system, a bare gold surface which has chiral phases was shown to prefer the adsorption of D‐type amino acid without relying on the organic selector layer on the surface.