A severe presentation of acute generalized exanthematous pustulosis with non‐infectious circulatory shock in an adolescent. Issue 5 (16th July 2021)

• Record Type: Journal Article
• Authors: O'Brian, Madeleine; Kolitz, Elysha; Jeong, Haneol S.; Cao, Lauren; Vandergriff, Travis; Glass, Donald A.; Dominguez, Arturo R.
• Is Part Of: Pediatric dermatology. Volume 38:Issue 5(2021)
• Page Start: 1267
• Page End: 1271
• Publication Date: 2021-07-16
• Subjects: acute generalized exanthematous pustulosis -- AGEP -- hypotension -- shock -- trimethoprim‐sulfamethoxazole; Pediatric dermatology -- Periodicals; Children -- Diseases -- Periodicals; 618.925
• DOI: 10.1111/pde.14704
• Languages: English
• ISSNs: 0736-8046

Abstract

Abstract: We present a severe case of acute generalized exanthematous pustulosis (AGEP) secondary to trimethoprim‐sulfamethoxazole complicated by non‐infectious circulatory shock in a 16‐year‐old boy. Hemodynamic instability has been reported as a complication of AGEP in adults, but is rarely observed in pediatric patients. The patient we present demonstrated characteristic cutaneous findings of AGEP including isolated non‐follicular, sterile pustules on a background of erythema with involvement at intertriginous areas and subsequently developed non‐infectious circulatory shock. This case expands the spectrum of possible clinical presentations for AGEP in pediatric patients.