Roles of ghrelin in left-ventricular remodelling after acute myocardial infarction. Issue 1 (5th July 2010)

• Record Type: Journal Article
• Authors: Kondo, Hideyuki; Hojo, Yukihiro; Takahashi, Nozomu; Ikemoto, Tomokazu; Aoki, Hirotaka; Dezaki, Katsuya; Kario, Kazuomi; Katsuki, Takaaki; Yada, Toshihiko; Shimada, Kazuyuki
• Is Part Of: Heart Asia. Volume 2:Issue 1(2010)
• Page Start: 1
• Page End: 4
• Publication Date: 2010-07-05
• Subjects: Acute coronary syndromes -- Acute coronary syndrome -- Ghrelin -- Metabolism -- Myocardial ischaemia -- Ventricular remodelling; AMI -- acute myocardial infarction -- BMI -- body mass index -- CPK-AUC -- creatine phosphokinase-area under the curve -- CRP -- C-reactive protein -- GH -- growth hormone -- IGF-1 -- insulin-like growth factor-1 -- LV -- left ventricular -- LVEDVI -- left ventricular end-diastolic volume index -- LVEF -- left ventricular ejection fraction -- PCI -- percutaneous coronary intervention
• DOI: 10.1136/ha.2009.000927
• Languages: English
• ISSNs: 2398-5968

Abstract

Abstract : Objective: The purpose of this study was to elucidate the role of ghrelin after acute myocardial infarction (AMI) in left ventricular (LV) remodelling. Design: Prospective observational study. Setting: Jichi Medical University Hospital. Patients: Fifty consecutive patients experiencing their first AMI. Interventions: Ghrelin was measured on the day of admission, day 7, day 14 and 6 months after AMI. Patients were treated by percutaneous coronary intervention, and successful myocardial reperfusion was accomplished within 12 h after onset. To analyse LV remodelling, the authors performed left ventriculographies on the day of admission and 6 months after AMI. Main outcome measures: Changes in LV volume. Results: Plasma ghrelin increased significantly after AMI (admission: 40.9±7.3; day 7: 89.5±11.0; day 14: 92.6±11.8 fmol/ml, p<0.0001). There was a significant correlation between ghrelin on day 14 and changes in LV volume over 6 months (r=+0.46, p<0.001). Multivariate regression analysis showed that ghrelin on day 14 is a significant predictor of LV remodelling after AMI (β=+0.44, p=0.001). Conclusion: To our knowledge, this is the first report that shows a relation between circulating ghrelin after AMI and the progression of LV remodelling in the chronic phase. The elevation of ghrelin after AMI might be a compensatory mechanism to attenuate LV remodelling.