USP52 inhibits cell proliferation by stabilizing PTEN protein in non-small cell lung cancer. Issue 10 (29th October 2021)

• Record Type: Journal Article
• Authors: Zhu, Maoshu; Zhang, Hui; Lu, Fuhua; Wang, Zhaowei; Wu, Yulong; Chen, Huoshu; Fan, Xin; Yin, Zhijiang; Liang, Fulong
• Is Part Of: Bioscience reports. Volume 41:Issue 10(2021)
• Publication Date: 2021-10-29
• Subjects: cell proliferation -- inhibition -- Non-small cell lung cancer -- PTEN -- stabilization -- USP52; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1042/BSR20210486
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract: Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer. Ubiquitination is closely related to the development of lung cancer. However, the biological importance of newly discovered ubiquitin-specific peptidase (USP) 52 (USP52) in NSCLC remained unclear. Here, our findings identify USP52 as a novel tumor suppressor of NSCLC, the low expression of USP52 predicts a poor prognosis for NSCLC patients. The present study demonstrates that USP52 inhibits cancer cell proliferation through down-regulation of cyclin D1 (CCND1) as well as AKT/mTOR signaling pathway inhibition. Meanwhile, USP25 also suppresses NSCLC progression via enhancing phosphatase and tensin homolog (PTEN) stability in cancer cells, which further indicates the significance/importance of USP52 in NSCLC suppression.