A therapeutic keypad lock decoded in drug resistant cancer cells. Issue 28 (24th June 2021)

• Record Type: Journal Article
• Authors: Turkoglu, Gulsen; Koygun, Gozde Kayadibi; Zafer Yurt, Mediha Nur; Pirencioglu, Seyda Nur; Erbas-Cakmak, Sundus
• Is Part Of: Chemical science. Volume 12:Issue 28(2021)
• Page Start: 9754
• Page End: 9758
• Publication Date: 2021-06-24
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d1sc02521j
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : Information processing therapeutics with an implemented keypad lock logic gate selects input order for activation in drug resistant cancer cells. Abstract : A molecular keypad lock that displays photodynamic activity when exposed to glutathione (GSH), esterase and light in the given order, is fabricated and its efficacy in drug resistant MCF7 cancer cells is investigated. The first two inputs are common drug resistant tumor markers. GSH reacts with the agent and shifts the absorption wavelength. Esterase separates the quencher from the structure, further activating the agent. After these sequential exposures, the molecular keypad lock is exposed to light and produces cytotoxic singlet oxygen. Among many possible combinations, only one 'key' can activate the agent, and initiate a photodynamic response. Paclitaxel resistant MCF7 cells are selectively killed. This work presents the first ever biological application of small molecular keypad locks.