Lower vitamin D levels are associated with higher systemic lupus erythematosus activity, but not predictive of disease flare-up. Issue 1 (10th June 2014)

• Record Type: Journal Article
• Authors: Schoindre, Yoland; Jallouli, Moez; Tanguy, Marie-Laure; Ghillani, Pascale; Galicier, Lionel; Aumaître, Olivier; Francès, Camille; Le Guern, Véronique; Lioté, Frédéric; Smail, Amar; Limal, Nicolas; Perard, Laurent; Desmurs-Clavel, Hélène; Thi Huong, Du Le; Asli, Bouchra; Kahn, Jean-Emmanuel; Sailler, Laurent; Ackermann, Félix; Papo, Thomas; Sacré, Karim; Fain, Olivier; Stirnemann, Jérôme; Cacoub, Patrice; Leroux, Gaëlle; Cohen-Bittan, Judith; Hulot, Jean-Sébastien; Lechat, Philippe; Musset, Lucile; Piette, Jean-Charles; Amoura, Zahir; Souberbielle, Jean-Claude; Costedoat-Chalumeau, Nathalie;
• Other Names: Astudillo Leonardo author non-byline.; Belizna Cristina author non-byline.; Belmatoug Nadia author non-byline.; Benveniste Olivier author non-byline.; Benyamine Audrey author non-byline.; Bezanahary Holly author non-byline.; Blanco Patrick author non-byline.; Bletry Olivier author non-byline.; Bodaghi Bahram author non-byline.; Bourgeois Pierre author non-byline.; Brihaye Benoît author non-byline.; Chatelus Emmanuel author non-byline.; Damade Richard author non-byline.; Daugas Eric author non-byline.; De-Gennes Christian author non-byline.; Delfraissy Jean-François author non-byline.; Delluc Céline author non-byline.; Delluc Aurélien author non-byline.; Duhaut Pierre author non-byline.; Dupuy Alain author non-byline.; Durieu Isabelle author non-byline.; EA Hang-Korng author non-byline.; Farge Dominique author non-byline.; Funck-Brentano Christian author non-byline.; Gandjbakhch Frédérique author non-byline.; Gellen-Dautremer Justine author non-byline.; Godeau Bertrand author non-byline.; Goujard Cécile author non-byline.; Grandpeix Catherine author non-byline.; Grange Claire author non-byline.; Grimaldi Lamiae author non-byline.; Guettrot Gaëlle author non-byline.; Guillevin Loïc author non-byline.; Hachulla Eric author non-byline.; Harle Jean-Robert author non-byline.; Haroche Julien author non-byline.; Hausfater Pierre author non-byline.; Jouquan Jean author non-byline.; Kaplanski Gilles author non-byline.; Keshtmand Homa author non-byline.; Khellaf Mehdi author non-byline.; Lambotte Olivier author non-byline.; Launay David author non-byline.; Levesque Hervé author non-byline.; Lidove Olivier author non-byline.; Liozon Eric author non-byline.; LY Kim author non-byline.; Mahevas Matthieu author non-byline.; Mariampillai Kubéraka author non-byline.; Mariette Xavier author non-byline.; Mathian Alexis author non-byline.; Mazodier Karin author non-byline.; Michel Marc author non-byline.; Morel Nathalie author non-byline.; Mouthon Luc author non-byline.; Ngack Rokiya author non-byline.; Ninet Jacques author non-byline.; Oksenhendler Eric author non-byline.; Pellegrin Jean-Luc author non-byline.; Peyr Olivier author non-byline.; Piette Anne-Marie author non-byline.; Poindron Vincent author non-byline.; Pourrat Jacques author non-byline.; Roux Fabienne author non-byline.; Saadoun David author non-byline.; Sahali Sabrinel author non-byline.; Saint-Marcoux Bernadette author non-byline.; Sarrot-Reynauld Françoise author non-byline.; Sellam Jérémie author non-byline.; Sene Damien author non-byline.; Serratrice Jacques author non-byline.; Seve Pascal author non-byline.; Sibilia Jean author non-byline.; Simon Claude author non-byline.; Sordet Christelle author non-byline.; Terrier Benjamin author non-byline.; Trad Salim author non-byline.; Viallard Jean-François author non-byline.; Vidal Elisabeth author non-byline.; Wechsler Bertrand author non-byline.; Weiller Pierre-Jean author non-byline.; Zahr Noël author non-byline.;
• Is Part Of: Lupus science & medicine. Volume 1:Issue 1(2014)
• Publication Date: 2014-06-10
• Subjects: vitamin D -- Systemic Lupus Erythematosus -- Autoimmune Diseases -- hydroxychloroquine; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1136/lupus-2014-000027
• Languages: English
• ISSNs: 2398-8851

Abstract

Abstract : Objectives: Growing evidence suggests that vitamin D plays a key role in the pathogenesis and progression of autoimmune diseases, including systemic lupus erythematosus (SLE). Recent studies have found an association between lower serum 25-hydroxyvitamin D (25(OH)D) levels and higher SLE activity. We studied the relationship between 25(OH)D levels and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score, and we assessed for the first time the role of vitamin D in predicting SLE flare-ups. Methods: Serum 25(OH)D levels were measured in 170 patients with SLE who were prospectively followed up for 6 months (Plaquenil LUpus Systemic study, ClinicalTrials.gov number NCT00413361 ). Results: The mean SLEDAI score was 2.03±2.43 and 12.3% patients had active disease (SLEDAI ≥6). The mean 25(OH)D level was 20.6±9.8 ng/mL. Deficiency (25(OH)D <10 ng/mL) was observed in 27 (15.9%), insufficiency (10≤25(OH)D<30) in 112 (65.9%) and optimal vitamin D status (25(OH)D≥30) in 31 (18.2%) patients. In multivariate analysis, female gender (p=0.018), absence of defined antiphospholipid syndrome (p=0.002) and higher creatinine clearance (p=0.004) were predictive of lower 25(OH)D levels. In multivariate analysis, lower 25(OH)D levels were associated with high SLE activity (p=0.02). Relapse-free survival rate was not statistically different according to the vitamin D status during the 6-month follow-up (p=0.22). Conclusions: We found a low vitamin D status in the majority of patients with SLE, and a modest association between lower 25(OH)D levels and high disease activity. There was no association between baseline 25(OH)D levels and relapse-free survival rate.