Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients. (8th August 2020)

• Record Type: Journal Article
• Authors: Bellon, Mathilde; Schweblin, Cecilia; Lambeng, Nathalie; Cherpillod, Pascal; Vazquez, Jessica; Lalive, Patrice H; Schibler, Manuel; Deffert, Christine
• Is Part Of: Clinical infectious diseases. Volume 73:Number 9(2021)
• Page Start: e3102
• Page End: e3105
• Publication Date: 2020-08-08
• Subjects: SARS-CoV-2 -- neurological manifestations -- COVID-19 -- intrathecal synthesis -- blood-brain barrier; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciaa1165
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: This study analyzed the cerebrospinal fluid features of 31 coronavirus disease 2019 (COVID-19) patients with neurological complications. We observed neither severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in the cerebrospinal fluid, nor intrathecal immunoglobulin G (IgG) synthesis but did observe signs of blood-brain barrier disruption. These results might serve as a basis for a better understanding of SARS-CoV-2 related neuropathogenesis.