Potential biomarkers and targets of mitochondrial dynamics. Issue 8 (9th August 2021)

• Record Type: Journal Article
• Authors: Li, Liyang; Qi, Ruixue; Zhang, Linlin; Yu, Yuexin; Hou, Jiayun; Gu, Yutong; Song, Dongli; Wang, Xiangdong
• Is Part Of: Clinical and translational medicine. Volume 11:Issue 8(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-08-09
• Subjects: lung diseases -- mitochondria -- mitochondrial dynamics -- mtDNA; Clinical medicine -- Periodicals; Medicine, Experimental -- Periodicals; Medical innovations -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 616.027
• DOI: 10.1002/ctm2.529
• Languages: English
• ISSNs: 2001-1326

Abstract

Abstract: Mitochondrial dysfunction contributes to the imbalance of cellular homeostasis and the development of diseases, which is regulated by mitochondria‐associated factors. The present review aims to explore the process of the mitochondrial quality control system as a new source of the potential diagnostic biomarkers and/or therapeutic targets for diseases, including mitophagy, mitochondrial dynamics, interactions between mitochondria and other organelles (lipid droplets, endoplasmic reticulum, endosomes, and lysosomes), as well as the regulation and posttranscriptional modifications of mitochondrial DNA/RNA (mtDNA/mtRNA). The direct and indirect influencing factors were especially illustrated in understanding the interactions among regulators of mitochondrial dynamics. In addition, mtDNA/mtRNAs and proteomic profiles of mitochondria in various lung diseases were also discussed as an example. Thus, alternations of mitochondria‐associated regulators can be a new category of biomarkers and targets for disease diagnosis and therapy. Abstract : 1. The mitochondria quality control system includes mitochondrial dynamics and mitophagy, which is closely related to cellular mesenchymal activations and metabolism reprogramming. 2. Mitochondria can contact with other organelles by the predominant interface of the outer membrane of mitochondria with endoplasmic reticulum, lysosomes, and lipid droplets. 3. The regulation of mitochondrial DNA/RNA transcription and post‐transcriptional modifications are closely related to physiological and pathological processes in various diseases.