68Ga-FAPI PET/CT Versus 18F-FDG PET/CT for the Evaluation of Disease Activity in Takayasu Arteritis. (20th October 2021)

• Record Type: Journal Article
• Authors: Wu, Simin; Pang, Yizhen; Zhao, Liang; Zhao, Long; Chen, Haojun
• Is Part Of: Clinical nuclear medicine. Volume 46:Number 10(2021)
• Page Start: 847
• Page End: 849
• Publication Date: 2021-10-20
• Subjects: 18F-FDG -- 68Ga-FAPI -- PET/CT -- Takayasu arteritis -- disease activity; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003692
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract: Evaluation of disease activity in Takayasu arteritis (TA) is challenging because clinical, biological, and imaging data do not always correlate. In this case, a 19-year-old woman with TA underwent 18 F-FDG PET/CT for evaluating disease activity. However, no abnormal 18 F-FDG uptake was observed in the large arteries. Follow-up with 68 Ga-FAPI PET/CT showed intense activity in the mildly thickened walls of bilateral carotid, subclavian arteries, and thoracic and abdominal aorta. This case presented an example where 68 Ga-FAPI outperformed 18 F-FDG for detecting active inflammation of TA. Therefore, 68 Ga-FAPI PET/CT may allow monitoring of disease activity and facilitate selecting the optimal therapy for TA patients.