COVID-19 and Cardiovascular Disease: From Bench to Bedside. Issue 8 (16th April 2021)

• Record Type: Journal Article
• Authors: Chung, Mina K.; Zidar, David A.; Bristow, Michael R.; Cameron, Scott J.; Chan, Timothy; Harding, Clifford V.; Kwon, Deborah H.; Singh, Tamanna; Tilton, John C.; Tsai, Emily J.; Tucker, Nathan R.; Barnard, John; Loscalzo, Joseph
• Is Part Of: Circulation research. Volume 128:Issue 8(2021)
• Page Start: 1214
• Page End: 1236
• Publication Date: 2021-04-16
• Subjects: angiotensin-converting enzyme 2 -- COVID-19 -- inflammation -- magnetic resonance imaging -- thrombosis; Cardiovascular system -- Periodicals; Blood -- Circulation -- Periodicals; Blood Circulation; Cardiovascular System; Vascular Diseases; Sang -- Circulation -- Périodiques; Appareil cardiovasculaire -- Périodiques; 612.1
• DOI: 10.1161/CIRCRESAHA.121.317997
• Languages: English
• ISSNs: 0009-7330

Abstract

Abstract : Supplemental Digital Content is available in the text. Abstract : A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential consequences on the cardiovascular health of millions of people who survive infection worldwide. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, can infect the heart, vascular tissues, and circulating cells through ACE2 (angiotensin-converting enzyme 2), the host cell receptor for the viral spike protein. Acute cardiac injury is a common extrapulmonary manifestation of COVID-19 with potential chronic consequences. This update provides a review of the clinical manifestations of cardiovascular involvement, potential direct SARS-CoV-2 and indirect immune response mechanisms impacting the cardiovascular system, and implications for the management of patients after recovery from acute COVID-19 infection.