Exome Sequencing for Prenatal Diagnosis in Nonimmune Hydrops Fetalis. Issue 3 (March 2021)

• Record Type: Journal Article
• Authors: Sparks, Teresa N.; Lianoglou, Billie R.; Adami, Rebecca R.; Pluym, Ilina D.; Holliman, Kerry; Duffy, Jennifer; Downum, Sarah L.; Patel, Sachi; Faubel, Amanda; Boe, Nina M.; Field, Nancy T.; Murphy, Aisling; Laurent, Louise C.; Jolley, Jennifer; Uy, Cherry; Slavotinek, Anne M.; Devine, Patrick; Hodoglugil, Ugur; van Ziffle, Jessica; Sanders, Stephan J.; MacKenzie, Tippi C.; Norton, Mary E.
• Is Part Of: Obstetrical & gynecological survey. Volume 76:Issue 3(2021)
• Page Start: 139
• Page End: 141
• Publication Date: 2021-03
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Surgery -- Periodicals; 618
• DOI: 10.1097/01.ogx.0000741420.32321.9d
• Languages: English
• ISSNs: 0029-7828

Abstract

Abstract : (Abstracted from N Engl J Med 2020;383:1746–1756) Nonimmune hydrops fetalis (NIHF) is a condition complicating approximately 1 in 1700 to 3000 pregnancies where the fetus develops an overload of fluid, causing a wide range of outcomes such as stillbirth, preterm birth, neonatal complications, or neonatal death. Standard genetic testing with microarray or karyotype identifies a genetic cause of hydrops approximately only 25% of the time.