Nonimmune Hydrops Fetalis — More Than Meets the Eye?. Issue 2 (24th June 2021)

• Record Type: Journal Article
• Authors: Kilby, M.D.
• Is Part Of: Obstetric anesthesia digest. Volume 41:Issue 2(2021)
• Page Start: 92
• Page End: 92
• Publication Date: 2021-06-24
• Subjects: Neonatal Morbidity and Mortality; Anesthesia in obstetrics -- Periodicals; Anesthesia in obstetrics -- Abstracts -- Periodicals; 617.968205
• DOI: 10.1097/01.aoa.0000744184.12263.01
• Languages: English
• ISSNs: 0275-665X

Abstract

Abstract : ( N Engl J Med . 2020;383:1785–1786) Nonimmune Hydrops Fetalis (NIHF) is typically defined as fetal fluid accumulation in two sites and affects up to 1 in 1, 700 fetuses. There are multiple causes, including chromosomal abnormalities and structural malformations. Perinatal mortality is high in pregnancies where NIHF is present in the first trimester. In two different studies, diagnostic variants were identified in 9% and 24% of fetuses with NIHF using exome sequencing.