Depletion of Aneuploid Cells in Human Embryos and Gastruloids. Issue 8 (August 2021)

• Record Type: Journal Article
• Authors: Yang, Min; Rito, Tiago; Metzger, Jakob; Naftaly, Jeffrey; Soman, Rohan; Hu, Jianjun; Albertini, David F.; Barad, David H.; Brivanlou, Ali H.; Gleicher, Norbert
• Is Part Of: Obstetrical & gynecological survey. Volume 76:Issue 8(2021)
• Page Start: 480
• Page End: 481
• Publication Date: 2021-08
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Surgery -- Periodicals; 618
• DOI: 10.1097/OGX.0000000000000954
• Languages: English
• ISSNs: 0029-7828

Abstract

Abstract : (Abstracted from Nat Cell Biol 2021;23:314–321) Despite it being current practice in vitro fertilization (IVF) protocols to exclude aneuploid embryos diagnosed through preimplantation genetic testing (PGT-A), it remains controversial whether or not this improves IVF outcomes. Both IVF pregnancies and spontaneous pregnancies demonstrate similar levels of mosaicism (12% vs 6.3%).