Pathophysiology of Hypertension: The Mosaic Theory and Beyond. Issue 7 (2nd April 2021)

• Record Type: Journal Article
• Authors: Harrison, David G.; Coffman, Thomas M.; Wilcox, Christopher S.
• Is Part Of: Circulation research. Volume 128:Issue 7(2021)
• Page Start: 847
• Page End: 863
• Publication Date: 2021-04-02
• Subjects: blood pressure -- history -- hypertension -- inflammation -- reactive oxygen species; Cardiovascular system -- Periodicals; Blood -- Circulation -- Periodicals; Blood Circulation; Cardiovascular System; Vascular Diseases; Sang -- Circulation -- Périodiques; Appareil cardiovasculaire -- Périodiques; 612.1
• DOI: 10.1161/CIRCRESAHA.121.318082
• Languages: English
• ISSNs: 0009-7330

Abstract

Abstract : Dr Irvine Page proposed the Mosaic Theory of Hypertension in the 1940s advocating that hypertension is the result of many factors that interact to raise blood pressure and cause end-organ damage. Over the years, Dr Page modified his paradigm, and new concepts regarding oxidative stress, inflammation, genetics, sodium homeostasis, and the microbiome have arisen that allow further refinements of the Mosaic Theory. A constant feature of this approach to understanding hypertension is that the various nodes are interdependent and that these almost certainly vary between experimental models and between individuals with hypertension. This review discusses these new concepts and provides an introduction to other reviews in this compendium of Circulation Research .