The role of PAMPs and DAMPs in the pathogenesis of acute and recurrent anterior uveitis. Issue 3 (4th March 2009)

• Record Type: Journal Article
• Authors: Wakefield, Denis; Gray, Paul; Chang, John; Di Girolamo, Nick; McCluskey, Peter
• Is Part Of: British journal of ophthalmology. Volume 94:Issue 3(2010)
• Page Start: 271
• Page End: 274
• Publication Date: 2009-03-04
• Subjects: Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjo.2008.146753
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : The pathogenesis of acute and recurrent anterior uveitis is poorly understood. Here, recent evidence is presented for the hypothesis that this disease may be associated with activation of receptors of the innate immune system, such as Toll-like receptors, by pathogen associated molecule patterns, such as lipopolysaccharide, derived from triggering gram negative bacteria. Acute anterior uveitis results in ocular tissue damage and the release of endogenous molecules (damage associated molecular patterns), such as heat shock proteins and S100 proteins that can also activate Toll-like receptors and thus perpetuate or reactivate intraocular inflammation.