Heart-type fatty acid binding protein is a novel prognostic marker in patients with non-ischaemic dilated cardiomyopathy. Issue 5 (30th December 2005)

• Record Type: Journal Article
• Authors: Komamura, K; Sasaki, T; Hanatani, A; Kim, J; Hashimura, K; Ishida, Y; Ohkaru, Y; Asayama, K; Tanaka, T; Ogai, A; Nakatani, T; Kitamura, S; Kangawa, K; Miyatake, K; Kitakaze, M
• Is Part Of: Heart. Volume 92:Issue 5(2006)
• Page Start: 615
• Page End: 618
• Publication Date: 2005-12-30
• Subjects: BNP, brain natriuretic peptide -- cTnT, cardiac troponin T -- DCM, dilated cardiomyopathy -- H-FABP, heart-type fatty acid binding protein; brain natriuretic peptide -- cardiac events -- cardiomyopathy -- fatty acid binding protein; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.2004.043067
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: To determine whether concentrations of heart-type fatty acid binding protein (H-FABP) measured before hospital discharge predict critical cardiac events in patients with idiopathic dilated cardiomyopathy (DCM). Patients: 92 consecutive patients with DCM were enrolled and followed up for four years. Main outcome measures: Serum concentrations of H-FABP, brain natriuretic peptide (BNP), cardiac troponin T before hospital discharge and survival rate. Results: 23 patients died of cardiac causes, received a left ventricular assist device or underwent heart transplantation during the four-year follow up. Univariate analyses showed that New York Heart Association functional class, heart rate, ejection fraction, serum H-FABP and plasma BNP were significant variables. According to multivariate analysis, serum H-FABP and plasma BNP concentrations were independent predictors of critical cardiac events. Cardiac troponin T before hospital discharge was not a predictor. The area under the receiver operating characteristic curve for death from critical cardiac events was similar between H-FABP and BNP. Patients with an H-FABP concentration at or above the median (⩾ 5.4 ng/ml) had a significantly lower survival rate than those below the median, according to analysis by log rank test (p < 0.0001). When combined with BNP concentration at or above the median (⩾ 138 pg/ml), H-FABP below the median predicted the worst prognosis among the combinations. Conclusions: The concentration of serum H-FABP before discharge from hospital may be an independent predictor for critical cardiac events in DCM.