Early famine exposure and adult disease risk based on a 10-year prospective study of Chinese adults. Issue 3 (8th November 2019)

• Record Type: Journal Article
• Authors: Meng, Ruogu; Yu, Canqing; Guo, Yu; Bian, Zheng; Si, Jiahui; Nie, Jia; Yang, Ling; Chen, Yiping; Du, Huaidong; Zhou, Liyuan; Liu, Yun; Chen, Junshi; Chen, Zhengming; Li, Liming; Lv, Jun
• Other Names: author non-byline.; Chen Junshi author non-byline.; Chen Zhengming author non-byline.; Clarke Robert author non-byline.; Collins Rory author non-byline.; Guo Yu author non-byline.; Li Liming author non-byline.; Lv Jun author non-byline.; Peto Richard author non-byline.; Walters Robin author non-byline.; Boxall Ruth author non-byline.; Bennett Derrick author non-byline.; Chang Yumei author non-byline.; Chen Yiping author non-byline.; Chen Zhengming author non-byline.; Clarke Robert author non-byline.; Du Huaidong author non-byline.; Gilbert Simon author non-byline.; Hacker Alex author non-byline.; Hill Mike author non-byline.; Holmes Michael author non-byline.; Iona Andri author non-byline.; Kartsonaki Christiana author non-byline.; Kerosi Rene author non-byline.; Kong Ling author non-byline.; Kurmi Om author non-byline.; Lancaster Garry author non-byline.; Lewington Sarah author non-byline.; Lin Kuang author non-byline.; McDonnell John author non-byline.; Millwood Iona author non-byline.; Nie Qunhua author non-byline.; Radhakrishnan Jayakrishnan author non-byline.; Ryder Paul author non-byline.; Sansome Sam author non-byline.; Schmidt Dan author non-byline.; Sherliker Paul author non-byline.; Sohoni Rajani author non-byline.; Stevens Becky author non-byline.; Turnbull Iain author non-byline.; Walters Robin author non-byline.; Wang Jenny author non-byline.; Wang Lin author non-byline.; Wright Neil author non-byline.; Yang Ling author non-byline.; Yang Xiaoming author non-byline.; Bian Zheng author non-byline.; Guo Yu author non-byline.; Han Xiao author non-byline.; Hou Can author non-byline.; Lv Jun author non-byline.; Pei Pei author non-byline.; Liu Chao author non-byline.; Tan Yunlong author non-byline.; Yu Canqing author non-byline.; Pang Zengchang author non-byline.; Gao Ruqin author non-byline.; Li Shanpeng author non-byline.; Wang Shaojie author non-byline.; Liu Yongmei author non-byline.; Du Ranran author non-byline.; Zang Yajing author non-byline.; Cheng Liang author non-byline.; Tian Xiaocao author non-byline.; Zhang Hua author non-byline.; Zhai Yaoming author non-byline.; Ning Feng author non-byline.; Sun Xiaohui author non-byline.; Li Feifei author non-byline.; Licang Silu Lv author non-byline.; Wang Junzheng author non-byline.; Hou Wei author non-byline.; Zeng Mingyuan author non-byline.; Jiang Ge author non-byline.; Zhou Xue author non-byline.; Yang Liqiu author non-byline.; He Hui author non-byline.; Yu Bo author non-byline.; Li Yanjie author non-byline.; Xu Qinai author non-byline.; Kang Quan author non-byline.; Guo Ziyan author non-byline.; Wang Dan author non-byline.; Hu Ximin author non-byline.; Chen Jinyan author non-byline.; Fu Yan author non-byline.; Fu Zhenwang author non-byline.; Wang Xiaohuan author non-byline.; Weng Min author non-byline.; Guo Zhendong author non-byline.; Wu Shukuan author non-byline.; Li Yilei author non-byline.; Li Huimei author non-byline.; Fu Zhifang author non-byline.; Wu Ming author non-byline.; Zhou Yonglin author non-byline.; Zhou Jinyi author non-byline.; Tao Ran author non-byline.; Yang Jie author non-byline.; Su Jian author non-byline.; Suzhou Fang liu author non-byline.; Zhang Jun author non-byline.; Hu Yihe author non-byline.; Lu Yan author non-byline.; Ma Liangcai author non-byline.; Tang Aiyu author non-byline.; Zhang Shuo author non-byline.; Jin Jianrong author non-byline.; Liu Jingchao author non-byline.; Tang Zhenzhu author non-byline.; Chen Naying author non-byline.; Huang Ying author non-byline.; Li Mingqiang author non-byline.; Meng Jinhuai author non-byline.; Pan Rong author non-byline.; Jiang Qilian author non-byline.; Lan Jian author non-byline.; Liu Yun author non-byline.; Wei Liuping author non-byline.; Zhou Liyuan author non-byline.; Chen Ningyu author non-byline.; Wang Ping author non-byline.; Meng Fanwen author non-byline.; Qin Yulu author non-byline.; Wang Sisi author non-byline.; Wu Xianping author non-byline.; Zhang Ningmei author non-byline.; Chen Xiaofang author non-byline.; Zhou Weiwei author non-byline.; Luo Guojin author non-byline.; Li Jianguo author non-byline.; Chen Xiaofang author non-byline.; Zhong Xunfu author non-byline.; Liu Jiaqiu author non-byline.; Sun Qiang author non-byline.; Ge Pengfei author non-byline.; Ren Xiaolan author non-byline.; Dong Caixia author non-byline.; Zhang Hui author non-byline.; Mao Enke author non-byline.; Wang Xiaoping author non-byline.; Wang Tao author non-byline.; Henan Xi zhang author non-byline.; Zhang Ding author non-byline.; Zhou Gang author non-byline.; Feng Shixian author non-byline.; Chang Liang author non-byline.; Fan Lei author non-byline.; Gao Yulian author non-byline.; He Tianyou author non-byline.; Sun Huarong author non-byline.; He Pan author non-byline.; Hu Chen author non-byline.; Zhang Xukui author non-byline.; Wu Huifang author non-byline.; He Pan author non-byline.; Zhejiang Min Yu author non-byline.; Hu Ruying author non-byline.; Wang Hao author non-byline.; Qian Yijian author non-byline.; Wang Chunmei author non-byline.; Xie Kaixu author non-byline.; Chen Lingli author non-byline.; Zhang Yidan author non-byline.; Pan Dongxia author non-byline.; Gu Qijun author non-byline.; Huang Yuelong author non-byline.; Yin Li author non-byline.; Liu Huilin author non-byline.; Fu Zhongxi author non-byline.; Xu Qiaohua author non-byline.; Xu Xin author non-byline.; Zhang Hao author non-byline.; Long Huajun author non-byline.; Li Xianzhi author non-byline.; Zhang Libo author non-byline.; Qiu Zhe author non-byline.;
• Is Part Of: Heart. Volume 106:Issue 3(2020)
• Page Start: 213
• Page End: 220
• Publication Date: 2019-11-08
• Subjects: cardiac risk factors and prevention -- epidemiology -- stroke -- chronic coronary disease; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/heartjnl-2019-315750
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: To comprehensively examine the potential impacts of prenatal experience of the Chinese Great Famine on chronic disease risks in the middle age. Methods: This study included 92 284 participants aged 39–51 years from China Kadoorie Biobank born around the famine period and without major chronic diseases at baseline. We categorised participants into non-famine births (born between 1 October 1956 and 30 September 1958, and 1 October 1962 and 30 September 1964) and famine births (born between 1 October 1959 and 30 September 1961). The outcomes were incident cardiovascular disease, cancer and respiratory system disease. Cox regression was used to estimate adjusted HR and 95% CI for famine exposure. Subgroup analyses were performed according to baseline characteristics. Results: During a median 10.1 years of follow-up, we identified 4626 incident ischaemic heart disease (IHD) cases, 7332 cerebrovascular disease cases, 3111 cancer cases and 16 081 respiratory system disease cases. In the whole population, prenatal famine exposure was not statistically associated with the risks of developing any chronic diseases in adulthood. However, for urban participants, compared with non-famine births, famine births had a higher risk of cerebrovascular disease (HR 1.18; 95% CI 1.09 to 1.28); such association was not shown for rural participants (p for interaction <0.001). Also, we observed the associations of prenatal famine exposure with IHD (HR 1.15; 95% CI 1.05 to 1.26) and cerebrovascular disease (HR 1.13; 95% CI 1.05 to 1.21) in participants with lower physical activity level, but not in those with higher ones (all p for interaction=0.003). Conclusion: Our findings indicate that prenatal exposure to the Chinese famine might be associated with an increased cardiovascular risk and such risk may be modified by adult lifestyle.