Cohort profile: design and methods in the eye and vision consortium of UK Biobank. Issue 2 (21st February 2019)

• Record Type: Journal Article
• Authors: Chua, Sharon Yu Lin; Thomas, Dhanes; Allen, Naomi; Lotery, Andrew; Desai, Parul; Patel, Praveen; Muthy, Zaynah; Sudlow, Cathie; Peto, Tunde; Khaw, Peng Tee; Foster, Paul J
• Other Names: author non-byline.; Aslam Tariq author non-byline.; Barman Sarah A author non-byline.; Barrett Jenny H author non-byline.; Bishop Paul author non-byline.; Blows Peter author non-byline.; Bunce Catey author non-byline.; Carare Roxana O author non-byline.; Chakravarthy Usha author non-byline.; Chan Michelle author non-byline.; Chua Sharon Yl author non-byline.; Crabb David P author non-byline.; Cumberland Philippa M author non-byline.; Day Alexander author non-byline.; Desai Parul author non-byline.; Dhillon Bal author non-byline.; Dick Andrew D author non-byline.; Egan Cathy author non-byline.; Ennis Sarah author non-byline.; Foster Paul author non-byline.; Fruttiger Marcus author non-byline.; Gallacher John Ej author non-byline.; F David author non-byline.; Gibson Jane author non-byline.; Gore Dan author non-byline.; Guggenheim Jeremy A author non-byline.; Hammond Chris J author non-byline.; Hardcastle Alison author non-byline.; Harding Simon P author non-byline.; Hogg Ruth E author non-byline.; Hysi Pirro author non-byline.; Keane Pearse A author non-byline.; T khaw Sir Peng author non-byline.; Khawaja Anthony P author non-byline.; Lascaratos Gerassimos author non-byline.; Lotery Andrew J author non-byline.; Macgillivray Tom author non-byline.; Mackie Sarah author non-byline.; Martin Keith author non-byline.; Mcgaughey Michelle author non-byline.; Mcguinness Bernadette author non-byline.; Mckay Gareth J author non-byline.; Mckibbin Martin author non-byline.; Mitry Danny author non-byline.; Moore Tony author non-byline.; Morgan James E author non-byline.; Muthy Zaynah A author non-byline.; O'sullivan Eoin author non-byline.; Owen Chris G author non-byline.; Patel Praveen author non-byline.; Paterson Euan author non-byline.; Peto Tunde author non-byline.; Petzold Axel author non-byline.; Rahi Jugnoo S author non-byline.; Rudnikca Alicja R author non-byline.; Self Jay author non-byline.; Sivaprasad Sobha author non-byline.; Steel David author non-byline.; Stratton Irene author non-byline.; Strouthidis Nicholas author non-byline.; Sudlow Cathie author non-byline.; Thomas Dhanes author non-byline.; Trucco Emanuele author non-byline.; Tufail Adnan author non-byline.; Vitart Veronique author non-byline.; Vernon Stephen A author non-byline.; Viswanathan Ananth C author non-byline.; Williams Cathy author non-byline.; Williams Katie author non-byline.; Woodside Jayne V author non-byline.; Yates Max M author non-byline.; Yip Jennifer author non-byline.; Zheng Yalin author non-byline.;
• Is Part Of: BMJ open. Volume 9:Issue 2(2019)
• Publication Date: 2019-02-21
• Subjects: epidemiology -- dementia -- medical retina -- medical ophthalmology; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2018-025077
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Purpose: To describe the rationale, methods and research potential of eye and vision measures available in UK Biobank. Participants: UK Biobank is a large, multisite, prospective cohort study. Extensive lifestyle and health questionnaires, a range of physical measures and collection of biological specimens are collected. The scope of UK Biobank was extended midway through data collection to include assessments of other measures of health, including eyes and vision. The eye assessment at baseline included questionnaires detailing past ophthalmic and family history, measurement of visual acuity, refractive error and keratometry, intraocular pressure (IOP), corneal biomechanics, spectral domain optical coherence tomography (OCT) of the macula and a disc–macula fundus photograph. Since recruitment, UK Biobank has collected accelerometer data and begun multimodal imaging data (including brain, heart and abdominal MRI) in 100 000 participants. Dense genotypic data and a panel of 20 biochemistry measures are available, and linkage to medical health records for the full cohort has begun. Findings to date: A total of 502 665 people aged between 40 and 69 were recruited to participate in UK Biobank. Of these, 117 175 took part in baseline assessment of vision, IOP, refraction and keratometry. A subgroup of 67 321 underwent OCT and retinal photography. The introduction of eye and vision measures in UK Biobank was accompanied by intensive training, support and a data monitoring quality control process. Future plans: UK Biobank is one of the largest prospective cohorts worldwide with extensive data on ophthalmic diseases and conditions. Data collection is an ongoing process and a repeat of the baseline assessment including the questionnaires, measurements and sample collection will be performed in subsets of 25 000 participants every 2–3 years. The depth and breadth of this dataset, coupled with its open-access policy, will create a powerful resource for all researchers to investigate the eye diseases in later life.