HIV-related excess mortality and age-related comorbidities in patients with HIV aged ≥60: a relative survival analysis in the French Dat'AIDS cohort. Issue 1 (25th January 2019)

• Record Type: Journal Article
• Authors: Hentzien, Maxime; Dramé, Moustapha; Delpierre, Cyrille; Allavena, Clotilde; Cabié, André; Cuzin, Lise; Rey, David; Pugliese, Pascal; Hédelin, Guy; Bani-Sadr, Firouzé
• Other Names: author non-byline.; Y Yazdanpanah author non-byline.; B Hoen author non-byline.; G Peytavin author non-byline.; C Jacomet author non-byline.; C Isnard-bagnis author non-byline.; D Peyramond author non-byline.; May Joly V author non-byline.; Brégigeon S author non-byline.; Zaegel-faucher O author non-byline.; Obry-roguet V author non-byline.; Laroche H author non-byline.; Orticoni M author non-byline.; Soavi Mj author non-byline.; Ressiot E author non-byline.; Padovani M Carta- author non-byline.; Ducassou Mj author non-byline.; Jaquet I author non-byline.; Galie S author non-byline.; Galinier A author non-byline.; Martinet P author non-byline.; Landon M author non-byline.; Ritleng As author non-byline.; Ivanova A author non-byline.; Betancourt C Blanco- author non-byline.; Debreux C author non-byline.; Lions C author non-byline.; Poizot-martin I author non-byline.; M Alvarez author non-byline.; N Biezunski author non-byline.; L Cuzin author non-byline.; A Debard author non-byline.; P Delobel author non-byline.; C Delpierre author non-byline.; C Fourcade author non-byline.; B Marchou author non-byline.; G Martin-blondel author non-byline.; L Porte author non-byline.; M Mularczyk author non-byline.; D Garipuy author non-byline.; K Saune author non-byline.; I Lepain author non-byline.; M Marcel author non-byline.; E Puntis author non-byline.; Pugliese P author non-byline.; Bentz L author non-byline.; Ceppi C author non-byline.; Cua E author non-byline.; Cottalorda J author non-byline.; Durant J author non-byline.; Ferrando S author non-byline.; Fuzibet Jg author non-byline.; Garraffo R author non-byline.; Mondain V author non-byline.; Naqvi A author non-byline.; Perbost I author non-byline.; Pillet S author non-byline.; Prouvost-keller B author non-byline.; Pradier C author non-byline.; SWehrlen-Pugliese author non-byline.; Roger Pm author non-byline.; Rosenthal E author non-byline.; Dellamonica P author non-byline.; Raffi F author non-byline.; Allavena C author non-byline.; Billaud E author non-byline.; Biron C author non-byline.; Bonnet B author non-byline.; Bouchez S author non-byline.; Boutoille D author non-byline.; Khatchatourian L author non-byline.; Brunet C author non-byline.; Jovelin T author non-byline.; Hall N author non-byline.; Bernaud C author non-byline.; Morineau P author non-byline.; Reliquet V author non-byline.; Aubry O author non-byline.; Point P author non-byline.; Besnier M author non-byline.; Hüe H author non-byline.; Cavellec M author non-byline.; Soria A author non-byline.; Pineau S author non-byline.; André-garnier E author non-byline.; Rodallec A author non-byline.; Ferré V author non-byline.; Leguen L author non-byline.; Lefebvre M author non-byline.; Grossi O author non-byline.; Cheret A author non-byline.; Choisy P author non-byline.; Duvivier C author non-byline.; Consigny Ph author non-byline.; Cessot G author non-byline.; Bossi P author non-byline.; Gergely A author non-byline.; Goesch J author non-byline.; Gilquin J author non-byline.; Benabdelmoumen G author non-byline.; Lanternier F author non-byline.; Charlier C author non-byline.; Amazzough K author non-byline.; Henry B author non-byline.; Pilmis B author non-byline.; Rouzaud C author non-byline.; Morgand M author non-byline.; Touam F author non-byline.; Louisin C author non-byline.; Lortholary O author non-byline.; Guery R author non-byline.; Danion F author non-byline.; Lourenco J author non-byline.; Parize P author non-byline.; Etienne N author non-byline.; Launay M author non-byline.; Rouzioux C author non-byline.; Fenoel V Avettand author non-byline.; Valantin Ma author non-byline.; Agher R author non-byline.; Katlama C author non-byline.; Abel S author non-byline.; Césaire R author non-byline.; Santos G Dos author non-byline.; Fagour L author non-byline.; Illiaquer M author non-byline.; Najioullah F author non-byline.; Nguyen D author non-byline.; Ouka M author non-byline.; Pierre-françois S author non-byline.; Pasquier J author non-byline.; Pircher M author non-byline.; Rozé B author non-byline.; Cabié A author non-byline.; Rey D author non-byline.; Fischer P author non-byline.; Partisani M author non-byline.; Cheneau C author non-byline.; Priester M author non-byline.; Bernard-henry C author non-byline.; Batard Ml author non-byline.; Mautort E De author non-byline.; Chirouze C author non-byline.; Gardiennet Q author non-byline.; Bani-sadr F author non-byline.; Berger Jl author non-byline.; N'Guyen Y author non-byline.; Lambert D author non-byline.; Kmiec I author non-byline.; Hentzien M author non-byline.; Migault C author non-byline.; Lebrun D author non-byline.; Brodard V author non-byline.; Cotte L author non-byline.; Chidiac C author non-byline.; Ferry T author non-byline.; Ader F author non-byline.; Biron F author non-byline.; Boibieux A author non-byline.; Miailhes P author non-byline.; Perpoint T author non-byline.; Schlienger I author non-byline.; Lippmann J author non-byline.; Braun E author non-byline.; Koffi J author non-byline.; Longuet C author non-byline.; Guéripel V author non-byline.; Augustin-normand C author non-byline.; Brochier C author non-byline.; Degroodt S author non-byline.;
• Is Part Of: BMJ open. Volume 9:Issue 1(2019)
• Publication Date: 2019-01-25
• Subjects: dat'aids cohort -- relative survival -- HIV infection -- comorbidities -- aged -- cardiovascular diseases; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2018-024841
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Objective: The objective was to evaluate the association between age-related comorbidities (ARCs) and 5-year HIV-related excess mortality in people living with HIV aged ≥60 years. Design: Cohort study using relative survival analysis (Estève's model). Setting: The French multicentre prospective Dat'AIDS cohort that involves 12 French hospitals. Participants: Inclusion of 1415 HIV-1 infected patients actively followed aged ≥60 years on January 2008, with a 5-year follow-up period in the late combination antiretroviral therapy era. Results: Among 1415 patients included, 154 died. By multivariable analysis, factors predictive of 5-year HIV-related excess mortality were non-AIDS-related cancer (adjusted excess HR (aEHR)=2.94; 95% CI 1.32 to 6.57), cardiovascular disease (aEHR=6.00; 95% CI 2.45 to 14.65), chronic renal disease (aEHR=4.86; 95% CI 2.24 to 10.53), cirrhosis (aEHR=3.58; 95% CI 1.25 to 10.28), hepatitis C co-infection (aEHR=3.63; 95% CI 1.44 to 9.12), body mass index<18.5 kg/m² (aEHR=4.10; 95% CI 1.61 to 10.48) and having a CD4 cell count ≤200/mm 3 (aEHR=5.79; 95% CI 2.28 to 14.69). Conclusions: ARCs, particularly cardiovascular disease and chronic renal disease, are predictive of HIV-related excess mortality, with an increase in hazard similar to that of CD4 cell count. Trial registration number: NCT02898987 .