Dose response for blood pressure and degree of cardiac beta-blockade with atenolol. Issue 646 (August 1979)

• Record Type: Journal Article
• Authors: Marshall, A. J.; Barritt, D. W.; Heaton, S.; Harry, J. D.
• Is Part Of: Postgraduate medical journal. Volume 55:Issue 646(1979)
• Page Start: 537
• Page End: 540
• Publication Date: 1979-08
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.55.646.537
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : The hypotensive effect of 25 mg, 50 mg, 75 mg, 100 mg and 0 mg of atenolol daily were compared in a double-blind within-patient study. The fall in blood pressure with 25 mg daily was not significantly different than with 100 mg. The dose response curve lies between 0 and 25 mg daily. Cardiac beta-blockade (measured by suppression of exercise tachycardia) was not maximal with 25 mg of atenolol daily. The dose response curves for beta-blockade and the hypotensive effect are not parallel.