Human leucocyte antigens A, B, C, and DRW in idiopathic "warm" autoimmune haemolytic anaemia. Issue 6216 (15th March 1980)

• Record Type: Journal Article
• Authors: Abdel-Khalik, A; Paton, L; White, A G; Urbaniak, S J
• Is Part Of: BMJ. Volume 280:Issue 6216(1980)
• Page Start: 760
• Page End: 761
• Publication Date: 1980-03-15
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.280.6216.760
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : Twenty patients with idiopathic "warm" autoimmune haemolytic anaemia and 40 controls were types concurrently for human leucocyte antigens (HLA) A, B, C, and DRW. There was a significantly stronger association of HLA-B8 with the disease (chi 2 = 10.39; p = 0.018) than HLA-DRW3 (chi 2 = 3.71; P = 0.35) and the patients also showed a significant increase in BW6 homozygosity (chi 2 = 7.13; P = 0.01) and a corresponding reduction in BW4 (chi 2 = 7.13; P = 0.02). (All p values corrected for number of antigens at each locus.) These findings suggest that susceptibility to idiopathic autoimmune haemolytic anaemia is associated more closely with the HLA-B locus than with DRW3.