Childhood B-Cell Acute Lymphoblastic Leukemia Following SARS CoV-2 Infection: A Potential Second "Hit" in Leukemogenesis. Issue 8 (23rd November 2021)

• Record Type: Journal Article
• Authors: Persaud, Yogindra; Shamoun, Mark; Chitlur, Meera; Des Rosier, Kyle J.; Taub, Jeffrey W.
• Is Part Of: Journal of pediatric hematology/oncology. Volume 43:Issue 8(2021)
• Page Start: e1241
• Page End: e1243
• Publication Date: 2021-11-23
• Subjects: ALL -- B-ALL -- childhood leukemia -- B-cell lymphoblastic leukemia -- delayed infectious theory -- COVID-19 -- SARS CoV-2; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000002037
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : The Coronavirus Disease 2019 (COVID-19) pandemic has become the worst pandemic in modern history. The lack of prior immunity to the virus has resulted in a high mortality rate, though children have fared better than adults, overall. We present a case of a child who developed B-cell acute lymphoblastic leukemia 1 week following a symptomatic COVID-19 infection. It is possible that this viral infection provided the "second hit" posited to occur in pediatric leukemogenesis as proposed by Dr Greaves, with his initial viral exposure occurring several weeks earlier.