Cyanosis Due to Methemoglobinemia as the Presenting Sign of Glucose-6-Phosphate Dehydrogenase Deficiency in a Child: Diagnostic and Clinical Implications. Issue 8 (7th November 2021)

• Record Type: Journal Article
• Authors: Pomoni, Angeliki; Aggeli, Ioanna; Loutsi, Eleni; Hatzimichael, Eleftheria; Chaliasos, Nikolaos; Makis, Alexandros
• Is Part Of: Journal of pediatric hematology/oncology. Volume 43:Issue 8(2021)
• Page Start: e1140
• Page End: e1144
• Publication Date: 2021-11-07
• Subjects: methemoglobinemia -- glucose-6-phosphate dehydrogenase deficiency -- child; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000001967
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : A previously healthy 3-year-old boy presented with pallor, jaundice, cyanosis, and a 24-hour history of vomiting and anorexia following fava bean ingestion. Clinical examination and laboratory findings were consistent with severe nonimmune hemolytic anemia with methemoglobinemia. Given the patient's history, a previously unrecognized glucose-6-phosphate dehydrogenase deficiency was suspected and diagnosed. The aim of this article is to delineate the possible coexistence of methemoglobinemia and glucose-6-phosphate dehydrogenase deficiency in children presented with acute hemolysis and discuss its management while reviewing the existing literature.