Combined treatment modality in pediatric infratentorial midline high‐grade glioma can lead to long‐term survival: A case study and review of literature. Issue Volume 5:Issues 3(2021) (6th September 2021)

• Record Type: Journal Article
• Authors: Das Majumdar, Saroj; Dhar, Sovan Sarang; Lalsangzuala, Chinzah; Sahu, Rabi; Purkait, Suvendu; Parida, Dillip
• Is Part Of: Precision radiation oncology. Volume 5:Issues 3(2021)
• Page Start: 213
• Page End: 218
• Publication Date: 2021-09-06
• Subjects: adjuvant chemoradiation -- midline high‐grade glioma -- pediatric CNS neoplasm -- survival
• DOI: 10.1002/pro6.1127
• Languages: English
• ISSNs: 2398-7324

Abstract

Abstract: Central nervous system high‐grade glioma (HGG) occurring in an infratentorial midline location is not commonly found in the pediatric population. Though pediatric HGGs appear similar to their adult counterparts histopathologically, they differ in molecular, genetic, and clinical characteristics. Evidence for the management of HGG is sparse in the literature. Surgery in the form of maximum safe resection is the backbone of management and has been variably supplemented with external beam radiotherapy and cytotoxic chemotherapy. The outcome, though largely dismal, has some positive surprises too. As shown in the presented case, the combined modality of management in a 5‐year‐old female child has resulted in a disease‐free survival of 3.5 years.