Direct, indirect and total effect of HIV coinfection on the risk of non‐liver‐related cancer in hepatitis C virus‐infected patients treated by direct‐acting antivirals: a mediation analysis. Issue 10 (17th August 2021)

• Record Type: Journal Article
• Authors: Chalouni, Mathieu; Pol, Stanislas; Sogni, Philippe; Fontaine, Helene; Lacombe, Karine; Lacombe, Jean‐Marc; Esterle, Laure; Dorival, Céline; Bourlière, Marc; Bani‐Sadr, Firouzé; de Ledinghen, Victor; Zucman, David; Larrey, Dominique; Salmon, Dominique; Carrat, Fabrice; Wittkop, Linda; Martinez, V.
• Other Names: Trimoulet P. investigator.; Izopet J. investigator.; Serfaty L. investigator.; Paradis V. investigator.; Spire B. investigator.; Carrieri P. investigator.; Valantin M.A. investigator.; Pialoux G. investigator.; Chas J. investigator.; Poizot‐Martin I. investigator.; Barange K. investigator.; Naqvi A. investigator.; Rosenthal E. investigator.; Bicart‐See A. investigator.; Bouchaud O. investigator.; Gervais A. investigator.; Lascoux‐Combe C. investigator.; Goujard C. investigator.; Duvivier C. investigator.; Neau D. investigator.; Morlat P. investigator.; Meyer L. investigator.; Boufassa F. investigator.; Autran B. investigator.; Roque A.M. investigator.; Solas C. investigator.; Costagliola D. investigator.; Piroth L. investigator.; Simon A. investigator.; Boué F. investigator.; Miailhes P. investigator.; Billaud E. investigator.; Aumaître H. investigator.; Rey D. investigator.; Peytavin G. investigator.; Petrov‐Sanchez V. investigator.; Levier A. investigator.; Usubillaga R. investigator.; Terris B. investigator.; Tremeaux P. investigator.; Katlama C. investigator.; Valantin M.A. investigator.; Stitou H. investigator.; Simon A. investigator.; Cacoub P. investigator.; Nafissa S. investigator.; Benhamou Y. investigator.; Charlotte F. investigator.; Fourati S. investigator.; Poizot‐Martin I. investigator.; Zaegel O. investigator.; Laroche H. investigator.; Tamalet C. investigator.; Pialoux G. investigator.; Chas J. investigator.; Callard P. investigator.; Bendjaballah F. investigator.; Amiel C. investigator.; Le Pendeven C. investigator.; Marchou B. investigator.; Alric L. investigator.; Barange K. investigator.; Metivier S. investigator.; Selves J. investigator.; Larroquette F. investigator.; Rosenthal E. investigator.; Naqvi A. investigator.; Rio V. investigator.; Haudebourg J. investigator.; Saint‐Paul M.C. investigator.; De Monte A. investigator.; Giordanengo V. investigator.; Partouche C. investigator.; Bouchaud O. investigator.; Martin A. investigator.; Ziol M. investigator.; Baazia Y. investigator.; Iwaka‐Bande V. investigator.; Gerber A. investigator.; Uzan M. investigator.; Bicart‐See A. investigator.; Garipuy D. investigator.; Ferro‐Collados M.J. investigator.; Selves J. investigator.; Nicot F. investigator.; Gervais A. investigator.; Yazdanpanah Y. investigator.; Adle‐Biassette H. investigator.; Alexandre G. investigator.; Peytavin G. investigator.; Lascoux‐Combe C. investigator.; Molina J.M. investigator.; Bertheau P. investigator.; Chaix M.L. investigator.; Delaugerre C. investigator.; Maylin S. investigator.; Krause J. investigator.; Girard P.M. investigator.; Wendum D. investigator.; Cervera P. investigator.; Adam J. investigator.; Viala C. investigator.; Vittecocq D. investigator.; Goujard C. investigator.; Quertainmont Y. investigator.; Teicher E. investigator.; Pallier C. investigator.; Lortholary O. investigator.; Duvivier C. investigator.; Rouzaud C. investigator.; Lourenco J. investigator.; Touam F. investigator.; Louisin C. investigator.; Avettand‐Fenoel V. investigator.; Gardiennet E. investigator.; Mélard A. investigator.; Neau D. investigator.; Ochoa A. investigator.; Blanchard E. investigator.; Castet‐Lafarie S. investigator.; Cazanave C. investigator.; Malvy D. investigator.; Dupon M. investigator.; Dutronc H. investigator.; Dauchy F. investigator.; Lacaze‐Buzy L. investigator.; Desclaux A. investigator.; Bioulac‐Sage P. investigator.; Trimoulet P. investigator.; Reigadas S. investigator.; Morlat P. investigator.; Lacoste D. investigator.; Bonnet F. investigator.; Bernard N. investigator.; Hessamfar M. investigator.; Paccalin J. F. investigator.; Martell C. investigator.; Pertusa M. C. investigator.; Vandenhende M. investigator.; Mercié P. investigator.; Malvy D. investigator.; Pistone T. investigator.; Receveur M.C. investigator.; Méchain M. investigator.; Duffau P. investigator.; Rivoisy C. investigator.; Faure I. investigator.; Caldato S. investigator.; Bioulac‐Sage P. investigator.; Trimoulet P. investigator.; Reigadas S. investigator.; Bellecave P. investigator.; Tumiotto C. investigator.; Pellegrin J.L. investigator.; Viallard J.F. investigator.; Lazzaro E. investigator.; Greib C. investigator.; Bioulac‐Sage P. investigator.; Trimoulet P. investigator.; Reigadas S. investigator.; Majerholc C. investigator.; Brollo M. investigator.; Farfour E. investigator.; Boué F. investigator.; Polo Devoto J. investigator.; Kansau I. investigator.; Chambrin V. investigator.; Pignon C. investigator.; Berroukeche L. investigator.; Fior R. investigator.; Abgrall S. investigator.; Favier M. investigator.; Deback C. investigator.; Lévy Y. investigator.; Dominguez S. investigator.; Lelièvre J.D. investigator.; Lascaux A.S. investigator.; Melica G. investigator.; Billaud E. investigator.; Raffi F. investigator.; Allavena C. investigator.; Reliquet V. investigator.; Boutoille D. investigator.; Biron C. investigator.; Lefebvre M. investigator.; Hall N. investigator.; Bouchez S. investigator.; Rodallec A. investigator.; Le Guen L. investigator.; Hemon C. investigator.; Miailhes P. investigator.; Peyramond D. investigator.; Chidiac C. investigator.; Ader F. investigator.; Biron F. investigator.; Boibieux A. investigator.; Cotte L. investigator.; Ferry T. investigator.; Perpoint T. investigator.; Koffi J. investigator.; Zoulim F. investigator.; Bailly F. investigator.; Lack P. investigator.; Maynard M. investigator.; Radenne S. investigator.; Amiri M. investigator.; Valour F. investigator.; Koffi J. investigator.; Zoulim F. investigator.; Bailly F. investigator.; Lack P. investigator.; Maynard M. investigator.; Radenne S. investigator.; Augustin‐Normand C. investigator.; Scholtes C. investigator.; Le‐Thi T.T. investigator.; Piroth L. investigator.; Chavanet P. investigator.; Duong Van Huyen M. investigator.; Buisson M. investigator.; Waldner‐Combernoux A. investigator.; Mahy S. investigator.; Binois R. investigator.; Simonet‐Lann A.L. investigator.; Croisier‐Bertin D. investigator.; Salmon Rousseau A. investigator.; Martins C. investigator.; Aumaître H. investigator.; Galim S. investigator.; Lambert D. investigator.; Nguyen Y. investigator.; Berger J.L. investigator.; Hentzien M. investigator.; Brodard V. investigator.; Roustant F. investigator.; Platterier P. investigator.; Kmiec I. investigator.; Traore L. investigator.; Youssouf M‐K. investigator.; Benmammar A. investigator.; Tateo M‐G. investigator.; Lepuil S. investigator.; Chloé Pomes investigator.; Sicart‐Payssan V. investigator.; Anriamiandrisoa S. investigator.; Pomes C. investigator.; Touam F. investigator.; Louisin C. investigator.; Mole M. investigator.; Catalan P. investigator.; Mebarki M. investigator.; Adda‐Lievin A. investigator.; Thilbaut P. investigator.; Ousidhoum Y. investigator.; Makhoukhi F.Z. investigator.; Braik O. investigator.; Bayoud R. investigator.; Gatey C. investigator.; Pietri M.P. investigator.; Le Baut V. investigator.; Ben Rayana R. investigator.; Barret F. investigator.; Chesnel C. investigator.; Beniken D. investigator.; Pauchard M. investigator.; Akel S. investigator.; Caldato S. investigator.; Rojas‐Rojas T. investigator.; Debreux C. investigator.; Chalal L. investigator.; Zelie J. investigator.; Soria A. investigator.; Cavellec M. investigator.; Breau S. investigator.; Fisher P. investigator.; Charles C. investigator.; Croisier‐Bertin D. investigator.; Ogoudjobi S. investigator.; Brochier C. investigator.; Thoirain‐Galvan V. investigator.; Le Cam M. investigator.; Carrieri P. investigator.; Conte V. investigator.; Dequae‐Merchadou L. investigator.; Desvallees M. investigator.; Gilbert C. investigator.; Gillet S. investigator.; Knight R. investigator.; Lemboub T. investigator.; Marcellin F. investigator.; Michel L. investigator.; Mora M. investigator.; Protopopescu C. investigator.; Roux P. investigator.; Spire B. investigator.; Tezkratt S. investigator.; Barré T. investigator.; Rojas T. investigator.; Baudoin M. investigator.; Santos M. investigator.; Di Beo V. investigator.; Nishimwe M. investigator.; Alric Laurent investigator.; Bonnet Delphine investigator.; Payssan‐Sicart Virginie investigator.; Pomes Chloe investigator.; Zoulim Fabien investigator.; Bailly François investigator.; Beaudoin Marjolaine investigator.; Giboz Dominique investigator.; Hartig‐Lavie Kerstin investigator.; Maynard Marianne investigator.; Raffi François investigator.; Billaud Eric investigator.; Boutoille David investigator.; Cavellec Morane investigator.; Cheraud‐Carpentier Marjorie investigator.; Cales Paul investigator.; Hubert Isabelle investigator.; Goepfert Pierre investigator.; Lannes Adrien investigator.; Lunel Françoise investigator.; Boursier Jérôme investigator.; Asselah Tarik investigator.; Boyer Nathalie investigator.; Giuily Nathalie investigator.; Castelnau Corinne investigator.; Scoazec Giovanna investigator.; Chibah Aziza investigator.; Keser Sylvie investigator.; Bonardi Karim investigator.; Vallet‐Pichard Anaïs investigator.; Foucher Juliette investigator.; Hiriart Jean‐Baptiste investigator.; Legendre Amandine investigator.; Chermak Faiza investigator.; Irlès‐Depé Marie investigator.; Ahmed Si Nafa Si investigator.; Ansaldi Christelle investigator.; Ben Amara Nisserine investigator.; Oules Valérie investigator.; Dunette Jacqueline investigator.; Tran Albert investigator.; Anty Rodolphe investigator.; Gelsi Eve investigator.; Truchi Régine investigator.; Thabut Dominique investigator.; Luckina Elena investigator.; Messaoudi Nadia investigator.; Moussali Joseph investigator.; Causse Xavier investigator.; De Dieuleveult Barbara investigator.; Goin Héloïse investigator.; Labarrière Damien investigator.; Potier Pascal investigator.; Ahmed Si Nafa Si investigator.; Ganne Nathalie investigator.; Grando‐Lemaire Véronique investigator.; Nahon Pierre investigator.; Brulé Séverine investigator.; Monard Rym investigator.; Guyader Dominique investigator.; Jezequel Caroline investigator.; Brener Audrey investigator.; Laligant Anne investigator.; Rabot Aline investigator.; Renard Isabelle investigator.; Habersetzer François investigator.; Baumert Thomas F investigator.; Doffoel Michel investigator.; Mutter Catherine investigator.; Simo‐Noumbissie Pauline investigator.; Razi Esma investigator.; Bronowicki Jean‐Pierre investigator.; Barraud Hélène investigator.; Bensenane Mouni investigator.; Nani Abdelbasset investigator.; Hassani‐Nani Sarah investigator.; Bernard Marie‐Albertine investigator.; Pageaux Georges‐Philippe investigator.; Bismuth Michael investigator.; Caillo Ludovic investigator.; Faure Stéphanie investigator.; Pierre Ripault Marie investigator.; Métivier Sophie investigator.; Bureau Christophe investigator.; Launay Sarah investigator.; Peron Jean Marie investigator.; Robic Marie Angèle investigator.; Tarallo Léa investigator.; Decaens Thomas investigator.; Faure Marine investigator.; Froissart Bruno investigator.; Hilleret Marie‐Noelle investigator.; Zarski Jean‐Pierre investigator.; Riachi Ghassan investigator.; Goria Odile investigator.; Grard Victorien investigator.; Montialoux Hélène investigator.; Leroy Vincent investigator.; François Muriel investigator.; Ouedraogo Christian investigator.; Pauleau Christelle investigator.; Varault Anne investigator.; Chazouillières Olivier investigator.; Andreani Tony investigator.; Angoulevant Bénédicte investigator.; Chevance Azeline investigator.; Serfaty Lawrence investigator.; Samuel Didier investigator.; Antonini Teresa investigator.; Coilly Audrey investigator.; Vallée Jean‐Charles Duclos investigator.; Tateo Mariagrazia investigator.; Abergel Armand investigator.; Bonny Corinne investigator.; Brigitte Chanteranne investigator.; Lamblin Géraldine investigator.; Muti Léon investigator.; Geist Claire investigator.; Babouri Abdenour investigator.; Filipe Virginie investigator.; Rosa Isabelle investigator.; Barrault Camille investigator.; Costes Laurent investigator.; Hagège Hervé investigator.; Merbah Soraya investigator.; Loustaud‐Ratti Véronique investigator.; Carrier Paul investigator.; Debette‐Gratien Maryline investigator.; Jacques Jérémie investigator.; Mathurin Philippe investigator.; Lassailly Guillaume investigator.; Artu Florent investigator.; Canva Valérie investigator.; Dharancy Sébastien investigator.; Louvet Alexandre investigator.; Minello Anne investigator.; Latournerie Marianne investigator.; Bardou Marc investigator.; Mouillot Thomas investigator.; D'Alteroche Louis investigator.; Bacq Yannick investigator.; Barbereau Didier investigator.; Nicolas Charlotte investigator.; Gournay Jérôme investigator.; Chevalier Caroline investigator.; Archambeaud Isabelle investigator.; Habes Sarah investigator.; Portal Isabelle investigator.; Amara Nisserine Ben investigator.; Botta‐Fridlund Danièle investigator.; Gellu‐Simeon Moana investigator.; Saillard Eric investigator.; Lafrance Marie‐Josée investigator.; Boursier Jérôme investigator.; Carrieri Patrizia investigator.; Delarocque Elisabeth investigator.; Fourati Slim investigator.; Nahon Pierre investigator.; Pageaux Georges‐Philippe investigator.; Petrov‐Sanchez Ventzislava investigator.; Vaux Sophie investigator.; Zoulim Fabien investigator.; Zucman‐Rossi Jessica investigator.; L'hennaff Marianne investigator.; Sizorn Michèle investigator.; Wadouachi Lena investigator.; Nailler Laure investigator.; Bousselet Alice investigator.; Caralp Mireille investigator.; Diallo Alpha investigator.; Nailler Laura investigator.; Wadouachi Lena investigator.; Petrov‐Sanchez Ventzi investigator.; Ammour Douae investigator.; Ayour Loubna investigator.; Benhida Jaouad investigator.; Chau Frederic investigator.; Goderel Isabelle investigator.; Hadi Warda investigator.; Lusivika‐Nzinga Clovis investigator.; Pannetier Grégory investigator.; Pinot François investigator.; Stahl Odile investigator.; Téloulé François investigator.;
• Is Part Of: HIV medicine. Volume 22:Issue 10(2021)
• Page Start: 924
• Page End: 935
• Publication Date: 2021-08-17
• Subjects: direct‐acting antiviral (DAA) treatment -- HCV -- HIV coinfection -- mediation analysis -- non‐liver‐related cancers; HIV infections -- Treatment -- Periodicals; HIV-positive persons -- Periodicals; HIV infections -- Treatment -- Decision making -- Periodicals; 616.9792
• DOI: 10.1111/hiv.13153
• Languages: English
• ISSNs: 1464-2662

Abstract

Abstract: Objectives: HIV‐coinfected patients experience higher incidences of non‐liver‐related cancers than HCV‐monoinfected patients. Chronic inflammation, immunosuppression, but also higher tobacco or alcohol consumption and metabolic dysregulation could explain this higher risk. We aimed to estimate the direct, indirect and total effects of HIV coinfection on the risk of non‐liver‐related cancers in HCV participants treated with direct‐acting antivirals (DAAs). Methods: Up to four HCV‐monoinfected participants from the ANRS CO22 HEPATHER cohort were matched by age and sex to HIV/HCV‐coinfected participants from the ANRS CO13 HEPAVIH cohort. Participants were followed from DAA initiation until the occurrence of a non‐liver‐related cancer. Counterfactual mediation analysis was carried out to estimate the direct (chronic inflammation and immunosuppression), indirect (tobacco and alcohol consumption and metabolic syndrome) and total effect of HIV coinfection on the risk of non‐liver‐related cancers. Results: 548 HIV/HCV‐coinfected and 2016 monoinfected participants were included. Overall, HIV coinfection was associated with a 3.7‐fold [95% confidence interval (CI): 1.7–7.0] higher risk of non‐liver‐related cancers in HCV participants. This increased risk was explained by significant direct effect [hazard ratio (HR) = 3.4, 95% CI: 1.7–6.6] but not indirect effect (HR = 1.1, 95% CI: 0.8–1.5) of HIV coinfection. Conclusions: In HCV participants treated with DAAs, the direct effect of HIV coinfection, reflecting chronic inflammation and immunosuppression, was associated with a 3.7‐fold higher risk of non‐liver‐related cancer. By contrast, the indirect effect of HIV coinfection, reflecting higher tobacco and alcohol consumption and metabolic dysregulation, was not significantly associated with the risk of non‐liver‐related cancers.