Screening for von Willebrand disease does not impact posttonsillectomy bleeding in a low‐risk population. Issue 12 (4th October 2021)

• Record Type: Journal Article
• Authors: Digiandomenico, Stefanie; Conley, Stephen F.; Johnson, Victoria P.; Christopherson, Pamela A.; Haberichter, Sandra L.; Zhang, Jian; Simpson, Pippa; Abshire, Thomas C.; Montgomery, Robert R.; Flood, Veronica H.
• Is Part Of: Pediatric blood & cancer. Volume 68:Issue 12(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-10-04
• Subjects: bleeding -- tonsillectomy -- von Willebrand disease; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.29371
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: Background: Bleeding is an important complication in children following tonsillectomy. Screening with coagulation tests prior to procedure is common to assess bleeding risk in the perioperative period, although ASH/ASPHO Choosing Wisely guidelines recommend against routine PT/PTT testing. Our aim was to compare von Willebrand factor antigen (VWF:Ag) and activity levels among patients with postoperative bleeding following tonsillectomy to evaluate for potential risk for bleeding. Procedure: Eligible subjects were aged 0–18 without significant personal or family history of major bleeding. Postoperative bleeding diaries were collected and symptoms measured using a postoperative bleeding score. Plasma VWF levels were drawn at time of anesthesia administration. Results: Postoperative bleeding occurred in 248 cases out of 1399 total subjects. Median VWF:Ag was 86 in patients with postoperative bleeding scores of 1–2, 86 for scores 3–4, 84 for scores 5–6, and 83 for scores >6, with no significant difference among groups ( p = .98). Additionally, no difference was observed for subjects with multiple days of postoperative bleeding as compared to those with only 1 day of postoperative bleeding. Finally, no difference in VWF:Ag was observed for subjects whose first reported bleed occurred early in the postoperative course compared to those whose first reported bleed occurred later. VWF:Ag does not correlate with severity of bleeding, time of onset of first bleeding event, or recurrence of bleeding in healthy children with no personal or family history of bleeding who have postoperative bleeding following tonsillectomy. Conclusions: This data does not support routine von Willebrand disease screening prior to tonsillectomy.