Cochleate Formulation Enhances the Stability of Lansoprazole in Acidic Condition. (14th July 2021)

• Record Type: Journal Article
• Authors: Goo, Yoon Tae; Jin, Chang Hwa; Kim, Min Song; Han, Sang Beom; Choi, Young Wook
• Is Part Of: Bulletin of the Korean Chemical Society. Volume 42:Number 10(2021)
• Page Start: 1281
• Page End: 1284
• Publication Date: 2021-07-14
• Subjects: Lansoprazole -- Cochleate -- Acidic stability -- Dimyristoyl phosphatidylcholine -- Dicetyl phosphate; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/bkcs.12360
• Languages: English
• ISSNs: 0253-2964

Abstract

Abstract : Lansoprazole (LSP)‐loaded cochleates were developed using dimyristoyl phosphatidylcholine (DMPC) and cholesterol in the presence or absence of dicetyl phosphate (DCP). Cochleates containing DCP exhibited unique cylindrical morphologies, resulting in improved LSP loading and enhanced stability in an acidic environment. Thus, we suggest that the use of negatively charged components, such as DCP, is needed to formulate cochleates using a neutrally charged lipid such as DMPC. Abstract : Lansoprazole (LSP)‐loaded cochleates were developed using dimyristoyl phosphatidylcholine (DMPC) and cholesterol in the presence or absence of dicetyl phosphate (DCP). Cochleates containing DCP exhibited unique cylindrical morphologies, resulting in improved LSP loading and enhanced stability in an acidic environment. Thus, we suggest that the use of negatively charged components, such as DCP, is needed to formulate cochleates using a neutrally charged lipid such as DMPC.