An Improved Sample Size Calculation Method for Score Tests in Generalized Linear Models. (2nd October 2021)

• Record Type: Journal Article
• Authors: Tang, Yongqiang; Zhu, Liang; Gu, Jiezhun
• Is Part Of: Statistics in biopharmaceutical research. Volume 13:Number 4(2021)
• Page Start: 415
• Page End: 424
• Publication Date: 2021-10-02
• Subjects: Exemplary dataset -- Negative binomial regression -- Noninferiority trials -- Power and sample size -- Score confidence interval; Pharmacy -- Statistical methods -- Periodicals; Pharmaceutical biotechnology -- Statistical methods -- Periodicals; Biopharmaceutics -- Periodicals; Biometry -- Periodicals; Pharmacy -- Statistical methods; Periodicals; 615.190727
• DOI: 10.1080/19466315.2020.1756398
• Languages: English
• ISSNs: 1946-6315

Abstract

Abstract: Self and Mauritsen developed a sample size determination procedure for score tests in generalized linear models under contiguous alternatives. Its performance may deteriorate when the effect size is large. We propose a modification of the Self–Mauritsen method by taking into account of the variance of the score statistic under both the null and alternative hypotheses, and extend the method to noninferiority trials. The modified approach is employed to calculate the sample size for the logistic regression and negative binomial regression in superiority and noninferiority trials. We further explain why the formulae recently derived by Zhu and Lakkis tend to underestimate the required sample size for the negative binomial regression. Numerical examples are used to demonstrate the accuracy of the proposed method.