Interleukin-1β and uric acid as potential second-trimester predictive biomarkers of preeclampsia. (3rd July 2021)

• Record Type: Journal Article
• Authors: Dogan, Keziban; Kural, Alev; Oztoprak, Yasin; Dogan, Murat
• Is Part Of: Hypertension in pregnancy. Volume 40:Number 3(2021)
• Page Start: 186
• Page End: 192
• Publication Date: 2021-07-03
• Subjects: Preeclampsia -- CRP -- interleukin-1β -- uric acid -- MPV -- vitamin D -- calcium -- magnesium; Hypertension in pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3261
• DOI: 10.1080/10641955.2021.1921793
• Languages: English
• ISSNs: 1064-1955

Abstract

ABSTRACT: Methods: The prospective study was conducted at the University Hospital from February 2020 to December 2020. The study population (n = 88) included women who later developed PE (n = 42), as well as women who were healthy at birth (n = 46) in the second trimester of pregnancy. Serum levels of CRP, IL-1β, uric acid, creatinine, AST, ALT, MPV, Hb, PC, vitamin D, Ca, and Mg were compared between the groups. Results: Serum IL-1β and uric acid levels were significantly higher in subjects who eventually developed PE compared with those who did not. Conclusions: IL-1β and uric acid may be a predictive markers for PE. Maternal serum IL-1β and uric acid levels in the second trimester of pregnancy may be a predictive markers for PE.