A new steroid with 7β, 8β-epoxidation from the deep sea-derived fungus Aspergillus penicillioides SD-311. Issue 9 (2nd September 2021)

• Record Type: Journal Article
• Authors: Chi, Lu-Ping; Yang, Sui-Qun; Li, Xiao-Ming; Li, Xiao-Dong; Wang, Bin-Gui; Li, Xin
• Is Part Of: Journal of Asian natural products research. Volume 23:Issue 9(2021)
• Page Start: 884
• Page End: 891
• Publication Date: 2021-09-02
• Subjects: Aspergillus penicillioides -- deep sea-derived fungus -- 7β, 8β-epoxy steroid -- marine natural products; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2020.1791096
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: 7β, 8β-epoxy-(22 E, 24 R )-24-methylcholesta-4, 22-diene-3, 6-dione (1 ), a new steroid, along with five known analogues (2 –6 ), was isolated from the deep sea-derived fungus, Aspergillus penicillioides SD-311. Strikingly, 1 possessed a rare 7, 8-epoxidation moiety. Meanwhile, this is the first time to report natural products from this fungus species. The structures were established by extensive spectroscopic analysis. The absolute configuration was determined by X-ray diffraction experiments. Compound 1 showed antibacterial activity against Vibrio anguillarum with MIC value of 32.0 µg/mL, while 2 displayed inhibitions against Edwardsiella tarda and Micrococcus luteus with MIC values both of 16 µg/mL. Graphical abstract: UF0001